hPSC衍生神经细胞研究

对于研究神经发育和疾病的研究人员来说，冷冻保存的人类多能干细胞 (hPSC) 衍生神经细胞可能是一种宝贵的工具。 查看更多 Using cryopreserved neural progenitor cells (NPCs) or lineage-restricted neuronal and glial precursors enables rapid and reproducible implementation of hPSC neural models, bypassing the need for time-consuming hPSC maintenance and neural induction steps. Furthermore, a reliable source of large quantities of cells with a reproducible phenotype is critical for high-throughput screening applications, such as drug screening and toxicology testing.

Highly pure cryopreserved hPSC-derived NPCs are available from various cell lines. These NPCs express the neural progenitor markers SOX1 and Nestin. The cells can be expanded with Neural Progenitor Medium 2 and passaged for over 10 passages without loss of differentiation capacity.

Cryopreserved hPSC-derived mixed neurons, dopaminergic neurons or astrocytes can be matured from their precursor states using the corresponding STEMdiff™ Maturation Kit.