小鼠重组Shh

声波刺猬

产品号 #(选择产品)

产品号 #78066_C

声波刺猬

概述

Sonic hedgehog (Shh)是hedgehog家族的一员,是一种分泌信号蛋白,在哺乳动物早期发育过程中具有重要的模式作用(Ho & Scott)。它在胚胎发育早期在多种组织中表达(Finco等人)。在中枢神经系统的模式化过程中,Shh直接作用于细胞,指定神经细胞的命运,调节少突胶质前体细胞和神经嵴细胞的增殖和存活,刺激增殖、分化和轴突生长(Ho & Scott;马蒂)。Shh也调节T细胞的分化和激活(Crompton等人)。重组小鼠Shh是一种具有完全生物活性的分子。

Subtype
Cytokines
 
Cell Type
Neural Stem and Progenitor Cells, Pluripotent Stem Cells
 
Species
Mouse
 
Area of Interest
Neuroscience, Stem Cell Biology
 
Purity
≥ 95%
 

Data Figures

(A) The biological activity of Mouse Recombinant Shh was tested by its ability to promote alkaline phosphatase production of CCL-226 cells. Alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.8 μg/mL.
(B) 2 μg of Mouse Recombinant Shh was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant Shh has a predicted molecular mass of 19.8 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78066, 78066.2, 78066.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78066, 78066.2, 78066.1
Lot #
All
Language
English

Resources and Publications

Educational Materials (1)

更多信息

更多信息
Species Mouse
Purity ≥ 95%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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