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小鼠重组Noggin

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产品号 #78061_C

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概述

Noggin结合并拮抗转化生长因子β (TGF-β)家族的骨形态发生蛋白（BMP）配体。Noggin支持维持在小鼠胚胎成纤维细胞（MEF）条件培养基中培养的未分化的人胚胎干细胞（Chaturvedi等人），并促进胚胎干细胞的多巴胺能分化和随后多巴胺神经元的存活（Chiba等人）。头蛋白对神经管、牙齿、毛囊、眼睛等外胚层结构的发育以及中胚层体和骨骼结构的形成至关重要。它还影响软骨形成、成骨和关节形成（Krause等）。

Subtype
Cytokines

Cell Type
Neural Stem and Progenitor Cells, Neurons, Pluripotent Stem Cells

Species
Mouse

Area of Interest
Neuroscience, Stem Cell Biology

Purity
≥ 95%

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Data Figures

(A) The biological activity of Mouse Recombinant Noggin was tested by its ability to inhibit BMP-4 induced alkaline phosphatase production of ATDC-5 cells. Inhibitition of BMP-4 induced alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which inhibition of alkaline phosphatase production is at 50% of maximum. The EC50 in the above example is 8.7 ng/mL (B) 2 μg of Mouse Recombinant Noggin was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant Noggin has a predicted molecular mass of 23.8 kDa.