人/小鼠重组TGF - β 3

转化生长因子β 3

产品号 #(选择产品)

产品号 #78131_C

转化生长因子β 3

总览

转化生长因子(TGF) β 3是TGF-β超家族的成员,可调节多种细胞表型。TGF-β 3与丝氨酸-苏氨酸激酶I型和II型受体结合,通过SMAD2/3蛋白激活信号转导,从而调节多种功能,包括细胞增殖、分化、伤口愈合、凋亡和代谢 (Massagué; McDowell et al.)。TGF - β 3可促进间充质基质细胞产生糖胺聚糖,刺激无疤痕愈合,并改善葡萄糖耐受性和脂肪细胞形态的表型变化 (Hall et al.; Holton et al.)。TGF-β 3诱导后额缝来源的间充质基质细胞增殖,并刺激成纤维细胞生长因子2和18的表达(James et al.)。

亚型
细胞因子,生长因子
 
细胞类型
间充质细胞,PSC衍生,间充质干/祖细胞
 
种属
人,小鼠
 
研究领域
干细胞生物学
 
纯度
≥ 95 %
 

Data Figures

(A) The biological activity of Human/Mouse Recombinant TGF-beta 3 was tested by its ability to inhibit proliferation of HT-2 cells in the presence of IL-4. Inhibition of cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation inhibition is at 50% of maximum. The EC50 in the example above is 0.0445 ng/mL. (B) 1 μg of Human/Mouse Recombinant TGF-beta 3 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78131.1, 78131.2, 78131
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78131.1, 78131.2, 78131
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

更多信息

更多信息
Species Human, Mouse
Purity ≥ 95%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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