产品号 #78131_C
转化生长因子β 3
转化生长因子(TGF) β 3是TGF-β超家族的成员,可调节多种细胞表型。TGF-β 3与丝氨酸-苏氨酸激酶I型和II型受体结合,通过SMAD2/3蛋白激活信号转导,从而调节多种功能,包括细胞增殖、分化、伤口愈合、凋亡和代谢 (Massagué; McDowell et al.)。TGF - β 3可促进间充质基质细胞产生糖胺聚糖,刺激无疤痕愈合,并改善葡萄糖耐受性和脂肪细胞形态的表型变化 (Hall et al.; Holton et al.)。TGF-β 3诱导后额缝来源的间充质基质细胞增殖,并刺激成纤维细胞生长因子2和18的表达(James et al.)。
亚型
细胞因子,生长因子
细胞类型
间充质细胞,PSC衍生,间充质干/祖细胞
种属
人,小鼠
研究领域
干细胞生物学
纯度
≥ 95 %
(A) The biological activity of Human/Mouse Recombinant TGF-beta 3 was tested by its ability to inhibit proliferation of HT-2 cells in the presence of IL-4. Inhibition of cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation inhibition is at 50% of maximum. The EC50 in the example above is 0.0445 ng/mL. (B) 1 μg of Human/Mouse Recombinant TGF-beta 3 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.
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Species | Human, Mouse |
---|---|
Purity | ≥ 95% |
用于人潜伏转化生长因子- β 1的检测和测定
转化生长因子β1
转化生长因子α
转化生长因子β3,不含动物成分
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