重组人TGF - α

转化生长因子α

产品号 #(选择产品)

产品号 #78123_C

转化生长因子α

总览

转化生长因子-α (TGF-α)是表皮生长因子(EGF)家族的一员,在正常上皮细胞、单核细胞、巨噬细胞、脑细胞、角质形成细胞和癌细胞中均有表达。TGF-α可与表皮生长因子受体(EGFR)结合,并激活酪氨酸激酶信号通路。在表皮和上皮细胞中,这可促使细胞增殖和分化。TGF-α与TGF-β在结构和基因上均无关联,两种配体通过不同的信号通路起作用。在体外实验终,TGF-α被证明可以刺激细胞的非锚定生长(Singh & Coffey)。

亚型
细胞因子,生长因子
 
细胞类型
气道细胞,上皮细胞,乳腺细胞,前列腺细胞
 
种属

 
研究领域
上皮细胞研究
 
纯度
≥ 95 %
 

Data Figures

(A) The biological activity of Human Recombinant TGF-alpha was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.2 ng/mL. (B) 2 μg of Human Recombinant TGF-alpha was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78123, 78123.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78123, 78123.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

更多信息

更多信息
Species Human
Purity ≥ 95%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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