产品号 #78123_C
Transforming growth factor alpha
概述
Transforming growth factor-alpha (TGF-α) a member of the epidermal growth factor (EGF) family that is expressed in normal epithelial cells, monocytes, macrophages, brain cells, keratinocytes, and cancer cells. TGF-α binds EGF receptor (EGFR) and activates tyrosine kinase signaling. In epidermal and epithelial cells, this results in proliferation and differentiation. TGF-α is not structurally or genetically related to TGF-β, and the two ligands act through different signaling pathways. In vitro, TGF-α was shown to stimulate anchorage-independent growth (Singh & Coffey).
Subtype
Cytokines, Growth Factors
Cell Type
Airway Cells, Epithelial Cells, Mammary Cells, Prostate Cells
Species
Human
Area of Interest
Epithelial Cell Biology
Purity
≥ 95%
Data Figures
(A) The biological activity of Human Recombinant TGF-alpha was tested by its ability to promote the proliferation of BALB/c 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.2 ng/mL. (B) 2 μg of Human Recombinant TGF-alpha was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant TGF-alpha Catalog #
78123, 78123.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant TGF-alpha Catalog #
78123, 78123.1 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Airway Epithelial Cell Research
Workflow Stages for Mammary Epithelial Cell Research
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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