重组人/小鼠TGF-β3, ACF

转化生长因子β3,不含动物成分

产品号 #(选择产品)

产品号 #78156_C

转化生长因子β3,不含动物成分

总览

转化生长因子(TGF)β3是TGF-β超家族的成员,可调节多种细胞表型。TGF-β3与丝氨酸-苏氨酸激酶 I 型和 II 型受体结合,并通过SMAD2/3蛋白激活信号转导,从而调节多种功能,包括细胞增殖、分化、伤口愈合、凋亡和代谢(Massagué;McDowell等)。TGF-β3可促进间充质基质细胞产生糖胺聚糖,刺激无疤痕愈合,并改善葡萄糖耐受性和脂肪细胞形态的表型变化(Hall等;Holton等)。TGF-β3可诱导后额缝隙来源的间充质干细胞增殖,并刺激成纤维细胞生长因子2和18的表达(James等)。本产品不含动物成分。

亚型
细胞因子,生长因子
 
细胞类型
间充质细胞,PSC衍生,间充质干/祖细胞
 
种属
人,小鼠
 
研究领域
干细胞生物学
 
制剂类别
Animal Component-Free
 
纯度
≥ 95 %
 

Data Figures

(A) The biological activity of Human/Mouse Recombinant TGF-beta 3, ACF was tested by its ability to inhibit proliferation of HT-2 cells in the presence of human IL-4. Inhibition of cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation inhibition is at 50% of maximum. The EC50 in the example above is 0.038 ng/mL. (B) 1 μg of Human/Mouse Recombinant TGF-beta 3, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78156
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78156
Lot #
All
Language
English

Applications

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Resources and Publications

Educational Materials (2)

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Species Human, Mouse
Formulation Category Animal Component-Free
Purity ≥ 95%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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