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抗人CD11b抗体，克隆ICRF44

抗人、恒河猴、食蟹猴CD11b的小鼠单克隆IgG1抗体
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产品号 #60040_C

抗人、恒河猴、食蟹猴CD11b的小鼠单克隆IgG1抗体

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总览
实验数据
产品说明书及文档
应用领域
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总览

ICRF44抗体与细胞外表位CD11b（整合素αM）反应，CD11b是一种约170 kDa的1型跨膜糖蛋白，与CD18非共价结合形成异二聚体Mac-1受体。Mac-1通过与ICAM-1 （CD54）、ICAM-2 （CD102）、ICAM-4 （CD242）、iC3b、肝素和纤维蛋白原等配体的相互作用，影响多个过程，包括中性粒细胞和单核细胞粘附于受刺激的内皮细胞，以及吞噬补体包被的颗粒。CD11b表达于粒细胞、单核细胞、NK细胞、树突状细胞、组织巨噬细胞以及T细胞和B细胞亚群的表面，并被用作区分naïve和记忆CD8+ T细胞的标志物。CD11b是一个相对较晚的髓系分化标志物，在大多数髓系造血祖细胞和更初始的细胞中检测不到。CD11b的某些突变会引起系统性红斑狼疮。研究发现，ICRF44抗体可抑制趋化因子fMLP引起的白细胞聚集。该抗体克隆已验证可用于使用EasySep™试剂盒（包括EasySep™人单核细胞富集试剂盒（产品号 #19059））分离的细胞的纯度评估验证，以及标记通过MesenCult™增殖试剂盒（人；产品号 #05411）培养的人间充质细胞。

亚型
一抗
 
靶抗原
CD11b
 
别名
C3biR，CR3，整合素 αM 链（CR3/Mac‑1），Mac-1，MAC1，Mo1
 
活性物种
Baboon，Chimpanzee，Common Marmoset，Cynomolgus，人，Pig，Rhesus
 
偶联
Alexa Fluor 488，APC，Biotin 或 生物素，FITC，PE，未偶联的
 
宿主物种
小鼠
 
细胞类型
髓系细胞
 
种属
人，非人灵长类，其它细胞系
 
应用
细胞分选，CyTOF，流式细胞术，功能学筛选，免疫细胞化学，免疫荧光，免疫组化，免疫沉淀，Western印迹
 
研究领域
免疫
 
克隆
ICRF44
 
基因编号
3684
 
同种型
IgG1，kappa
 

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Data Figures

Data for Alexa Fluor® 488-Conjugated

Figure 1. Data for Alexa Fluor® 488-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD11b Antibody, Clone ICRF44, Alexa Fluor® 488 (filled histogram) or a mouse IgG1, kappa Alexa Fluor® 488 isotype control antibody (solid line histogram).

Data for PE-Conjugated

Figure 2. Data for PE-Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD11b Antibody, Clone ICRF44, PE (filled histogram) or a mouse IgG1, kappa PE isotype control antibody (solid line histogram).

Data for Unconjugated

Figure 3. Data for Unconjugated

Flow cytometry analysis of human whole blood nucleated cells labeled with Anti-Human CD11b Antibody, Clone ICRF44, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (Catalog #60138FI) (filled histogram), or a mouse IgG1, kappa isotype control antibody, followed by Goat Anti­Mouse IgG (H+L) Antibody, Polyclonal, FITC (solid line histogram).

Data for APC-Conjugated

Figure 4. Data for APC-Conjugated

Flow cytometry analysis of human whole blood nucleated cells labeled with Anti-Human CD11b Antibody, Clone ICRF44, APC (filled histogram) or a mouse IgG1, kappa isotype control antibody, APC (solid line histogram).

Data for Biotin-Conjugated

Figure 5. Data for Biotin-Conjugated

Flow cytometry analysis of human whole blood nucleated cells labeled with Anti-Human CD11b Antibody, Clone ICRF44, Biotin followed by streptavidin (SAV) APC (filled histogram), or a biotinylated mouse IgG1, kappa isotype control antibody followed by SAV APC (solid line histogram).

Data for FITC-Conjugated

Figure 6. Data for FITC-Conjugated

Flow cytometry analysis of human whole blood nucleated cells labeled with Anti-Human CD11b Antibody, Clone ICRF44, FITC (filled histogram) or a mouse IgG1, kappa isotype control antibody, FITC (solid line histogram).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD11b Antibody, Clone ICRF44, Alexa Fluor® 488
Catalog #
60040AD, 60040AD.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD11b Antibody, Clone ICRF44, APC
Catalog #
60040AZ, 60040AZ.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD11b Antibody, Clone ICRF44, FITC
Catalog #
60040FI, 60040FI.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD11b Antibody, Clone ICRF44, PE
Catalog #
60040PE, 60040PE.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human CD11b Antibody, Clone ICRF44
Catalog #
60040
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD11b Antibody, Clone ICRF44, Alexa Fluor® 488
Catalog #
60040AD, 60040AD.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD11b Antibody, Clone ICRF44, APC
Catalog #
60040AZ, 60040AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD11b Antibody, Clone ICRF44, FITC
Catalog #
60040FI, 60040FI.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD11b Antibody, Clone ICRF44, PE
Catalog #
60040PE, 60040PE.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD11b Antibody, Clone ICRF44
Catalog #
60040
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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更多信息
Species Human, Non-Human Primate, Other
Clone ICRF44
Gene Id 3684
Alternative Names C3biR, CR3, Integrin αM chain, Mac-1, MAC1, Mo1
Isotype IgG1, kappa
Legal Statement: Alexa Fluor is a registered trademark of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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