重组人VEGF-165

血管内皮生长因子,不含动物成分

产品号 #(选择产品)

产品号 #78159_C

血管内皮生长因子,不含动物成分

总览

血管内皮生长因子(VEGF-165)是一种肝素结合型同源二聚体糖蛋白,参与胚胎血管生成和血管生成。VEGF与VEGFR-1 (R1)和VEGFR-2 (R2)结合,激活Raf/MEK/ERK和PI3K/AKT通路(Ferrara等)。它在体外和体内的神经发生中均发挥着重要作用(Storkebaum等)。它对中枢神经系统的神经元具有神经营养作用,并促进多巴胺能神经元和星形胶质细胞的生长和存活。VEGF还促进血管内皮细胞的生长和存活,单核细胞趋化以及粒细胞-巨噬细胞祖细胞的集落形成(Ferrara等)。VEGF-165包含两条多肽链,每条链由165个氨基酸组成。本产品不含动物成分。

亚型
细胞因子,生长因子
 
细胞类型
血管生成细胞,内皮细胞,造血干/祖细胞,间充质干/祖细胞,中胚层,PSC衍生,神经干/祖细胞,多能干细胞
 
种属

 
研究领域
血管生成细胞研究,内皮细胞研究,神经科学,干细胞生物学
 
制剂类别
Animal Component-Free
 
纯度
≥ 95 %
 

Data Figures

(A) The biological activity of Human Recombinant VEGF-165, ACF was tested by the ability to promote the proliferation of HUVECs. Cell proliferation was measured after 88 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 3.35 ng/mL. (B) Human Recombinant VEGF-165, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78159, 78159.2, 78159.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78159, 78159.2, 78159.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

更多信息

更多信息
Species Human
Formulation Category Animal Component-Free
Purity ≥ 95%
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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