产品号 #78159_C
血管内皮生长因子,不含动物成分
血管内皮生长因子(VEGF-165)是一种肝素结合型同源二聚体糖蛋白,参与胚胎血管生成和血管生成。VEGF与VEGFR-1 (R1)和VEGFR-2 (R2)结合,激活Raf/MEK/ERK和PI3K/AKT通路(Ferrara等)。它在体外和体内的神经发生中均发挥着重要作用(Storkebaum等)。它对中枢神经系统的神经元具有神经营养作用,并促进多巴胺能神经元和星形胶质细胞的生长和存活。VEGF还促进血管内皮细胞的生长和存活,单核细胞趋化以及粒细胞-巨噬细胞祖细胞的集落形成(Ferrara等)。VEGF-165包含两条多肽链,每条链由165个氨基酸组成。本产品不含动物成分。
亚型
细胞因子,生长因子
细胞类型
血管生成细胞,内皮细胞,造血干/祖细胞,间充质干/祖细胞,中胚层,PSC衍生,神经干/祖细胞,多能干细胞
种属
人
研究领域
血管生成细胞研究,内皮细胞研究,神经科学,干细胞生物学
制剂类别
Animal Component-Free
纯度
≥ 95 %
(A) The biological activity of Human Recombinant VEGF-165, ACF was tested by the ability to promote the proliferation of HUVECs. Cell proliferation was measured after 88 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 3.35 ng/mL. (B) Human Recombinant VEGF-165, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.
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Species | Human |
---|---|
Formulation Category | Animal Component-Free |
Purity | ≥ 95% |
成纤维细胞生长因子10
激活素A,不含动物成分
骨形态发生蛋白2,不含动物成分
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