重组人 FGF-10 (KGF-2)

成纤维细胞生长因子10

产品号 #(选择产品)

产品号 #78037_C

成纤维细胞生长因子10

总览

成纤维细胞生长因子 10 (FGF-10) 是成纤维细胞生长因子 (FGF) 家族的成员,主要在胚胎发育过程中由间充质成纤维细胞表达 (Emoto et al.; Igarashi et al.)。它与成纤维细胞生长因子受体 2-IIIb (FGFR2-IIIb) 具有高亲和力结合,对 FGFR1-IIIb 的亲和力较低 (Beer et al.)。FGF-10 和 FGF-7 具有相似的受体结合特性和靶细胞特异性,但受细胞外基质成分的不同调控 (Emoto et al.; Igarashi et al.)。FGF-10 已被证明能够介导上皮-间充质相互作用,这对肺发育至关重要 (Sekine et al; Ware & Matthay)。 FGF-10 还在肺驻留间充质干细胞 (MSCs) 的动员和增殖以及对急性肺损伤的保护和修复 (Tong et al.; Ware & Matthay) 以及人多能干细胞向产生胰岛素的胰腺样细胞的内胚层分化中发挥作用。(Takeuchi et al.)

亚型
细胞因子,生长因子
 
细胞类型
内胚层,PSC衍生,造血干/祖细胞,角质形成细胞,乳腺细胞,间充质干/祖细胞,神经细胞,PSC衍生,神经干/祖细胞,多能干细胞,前列腺细胞
 
种属

 
研究领域
上皮细胞研究,神经科学,干细胞生物学
 
纯度
≥ 95 %
 

Data Figures

(A) The biological activity of Human Recombinant FGF-10 (KGF-2) was tested by its ability to promote the proliferation of 4MBr-5 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 20 ng/mL. (B) 2 μg of Human Recombinant FGF-10 (KGF-2) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant FGF-10 (KGF-2) has a predicted molecular mass of 19.3 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78037.1, 78037.2, 78037, 78037.3
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78037.1, 78037.2, 78037, 78037.3
Lot #
All
Language
English

Resources and Publications

Educational Materials (2)

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Species Human
Purity ≥ 95%
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