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人/小鼠重组激活素A，ACF

激活素A，不含动物成分
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产品号 #78132_C

激活素A，不含动物成分

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总览
实验数据
产品说明书及文档
应用领域
相关材料与文献
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总览

激活素A是转化生长因子β (TGF-β) 蛋白家族的一员，该家族蛋白在发育过程中由多种细胞类型产生（Gurdon et al.）。它是一种二硫键连接的同型二聚体（两条β - A链），可与I型（Act RI-A和Act RI-B）和II型（Act RII-A和Act RII-B）丝氨酸-苏氨酸激酶受体的异聚物复合物结合（Attisano et al.）。激活素主要通过SMAD2/3蛋白发出信号来调节多种功能，包括细胞增殖、分化、伤口愈合、凋亡和代谢（McDowell et al.）。激活素A维持人胚胎干细胞的未分化状态(James et al.; Xiao et al.)，并促进人胚胎干细胞分化为定形内胚层（D’Amour et al.）。本产品不含动物成分。

亚型
细胞因子
 
细胞类型
内胚层，PSC衍生，中胚层，PSC衍生，其它细胞系，多能干细胞
 
种属
人，小鼠
 
研究领域
上皮细胞研究，干细胞生物学
 
制剂类别
Animal Component-Free
 
纯度
≥ 95 %
 

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Data Figures

(A) The biological activity of Human/Mouse Recombinant Activin A, ACF was tested by its ability to inhibit proliferation of MPC-11 cells. Inhibition of cell proliferation was measured after 66 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation inhibition is at 50% of maximum. The EC50 in the example above is 0.436 ng/mL. (B) 1 μg of Human/Mouse Recombinant Activin A, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human/Mouse Recombinant Activin A, ACF
Catalog #
78132, 78132.1, 78132.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human/Mouse Recombinant Activin A, ACF
Catalog #
78132, 78132.1, 78132.2
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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Species Human, Mouse
Formulation Category Animal Component-Free
Purity ≥ 95%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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