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人重组IL-10， ACF

白细胞介素10，不含动物成分
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产品号 #（选择产品）

产品号 #78144_C

白细胞介素10，不含动物成分

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总览
实验数据
产品说明书及文档
应用领域
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总览

白细胞介素10（IL-10）是II类细胞因子IL-10家族的创始成员。所有IL-10细胞因子家族成员都有一个由α-螺旋折叠组成的四螺旋束。IL-10与其受体结合后，通过JAK1和STAT3激活信号传导。它由树突状细胞、巨噬细胞、CD4+ T细胞以及肥大细胞、NK细胞、中性粒细胞和B细胞在特定刺激条件下产生（Saraiva & O'Garra）。IL-10可以抑制促炎细胞因子的表达并促进愈合过程，对Treg细胞的功能至关重要。IL-10还能促进B细胞增殖、免疫球蛋白分泌和II类MHC表达，而巨噬细胞产生的IL-10能抑制邻近巨噬细胞的活化，从而实现一定程度的自我调节（Ouyang et al.）。本产品不含动物成分。

亚型
细胞因子
 
别名
BTCGF；CSIF；细胞因子合成抑制因子；白细胞介素 10；TGIF
 
细胞类型
树突状细胞（DCs），造血干/祖细胞，髓系细胞，神经元，T 细胞
 
种属
人
 
研究领域
免疫，神经科学，干细胞生物学
 
制剂类别
Animal Component-Free
 
纯度
≥ 97 %
 

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Data Figures

(A) The biological activity of Human Recombinant IL-10, ACF was tested by its ability to promote the proliferation of MC/9 cells in the presence of human IL-4. Cell proliferation was measured after 48 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is 1.95 ng/mL. (B) 1 μg of Human Recombinant IL-10, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet 1
Product Name
Human Recombinant IL-10, ACF
Catalog #
78144.1, 78144.2
Lot #
1000077366 or higher
Language
English
Document Type
Product Information Sheet 2
Product Name
Human Recombinant IL-10, ACF
Catalog #
78144.1, 78144.2
Lot #
1000077365 or lower
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-10, ACF
Catalog #
78144.1, 78144.2
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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Species Human
Formulation Category Animal Component-Free
Alternative Names BTCGF, CSIF, Cytokine synthesis inhibitory factor, Interleukin10, TGIF
Purity ≥ 97%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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