产品号 #78144_C
白细胞介素10,不含动物成分
白细胞介素10(IL-10)是II类细胞因子IL-10家族的创始成员。所有IL-10细胞因子家族成员都有一个由α-螺旋折叠组成的四螺旋束。IL-10与其受体结合后,通过JAK1和STAT3激活信号传导。它由树突状细胞、巨噬细胞、CD4+ T细胞以及肥大细胞、NK细胞、中性粒细胞和B细胞在特定刺激条件下产生(Saraiva & O'Garra)。IL-10可以抑制促炎细胞因子的表达并促进愈合过程,对Treg细胞的功能至关重要。IL-10还能促进B细胞增殖、免疫球蛋白分泌和II类MHC表达,而巨噬细胞产生的IL-10能抑制邻近巨噬细胞的活化,从而实现一定程度的自我调节(Ouyang et al.)。本产品不含动物成分。
亚型
细胞因子
别名
BTCGF;CSIF;细胞因子合成抑制因子;白细胞介素 10;TGIF
细胞类型
树突状细胞(DCs),造血干/祖细胞,髓系细胞,神经元,T 细胞
种属
人
研究领域
免疫,神经科学,干细胞生物学
制剂类别
Animal Component-Free
纯度
≥ 97 %
(A) The biological activity of Human Recombinant IL-10, ACF was tested by its ability to promote the proliferation of MC/9 cells in the presence of human IL-4. Cell proliferation was measured after 48 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is 1.95 ng/mL. (B) 1 μg of Human Recombinant IL-10, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.
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Species | Human |
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Formulation Category | Animal Component-Free |
Alternative Names | BTCGF, CSIF, Cytokine synthesis inhibitory factor, Interleukin10, TGIF |
Purity | ≥ 97% |
人T细胞激活扩增试剂
通过免疫磁珠负选分离出无磁珠标记的人T细胞
冻存的人原代细胞
白介素10
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