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重组人 IL-10

白介素10
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产品号 #78024_C

白介素10

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总览
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总览

白介素 10 (IL-10) 是 II 类细胞因子 IL-10 家族的初始成员。所有 IL-10 细胞因子家族成员均具有由 α 螺旋折叠组成的四螺旋束。IL-10 与其受体结合后，通过 JAK1 和 STAT3 激活信号传导。它由树突状细胞、巨噬细胞、CD4+ T 细胞以及肥大细胞、NK 细胞、中性粒细胞和 B 细胞在特定刺激条件下产生 (Saraiva & O'Garra)。IL-10 可以抑制促炎细胞因子的表达并促进愈合过程，并且对调节性 T 细胞的功能至关重要。 IL-10 还能增强 B 细胞增殖、免疫球蛋白分泌和 II 类 MHC 表达，而巨噬细胞产生的 IL-10 则抑制邻近巨噬细胞的活化，从而实现一定程度的自我调节（Ouyang et al.）。

亚型
细胞因子
 
细胞类型
树突状细胞（DCs），造血干/祖细胞，髓系细胞，神经元，T 细胞
 
种属
人
 
研究领域
免疫，神经科学，干细胞生物学
 
纯度
≥ 95 %
 

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Data Figures

(A) The biological activity of Human Recombinant IL-10 was tested by its ability to promote the proliferation of MC/9 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.2 ng/mL.
(B) 5 μg of Human Recombinant IL-10 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-10 has a predicted molecular mass of 18 - 19 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant IL-10
Catalog #
78024.2, 78024.1, 78024
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-10
Catalog #
78024.2, 78024.1, 78024
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (3)

Tools for Your Immunology Research
Brochure
Tools for Your Immunology Research
Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Human Immune Cytokines
Wallchart
Human Immune Cytokines

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Species Human
Purity ≥ 95%
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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