产品号 #78174_C
转化生长因子β 2
转化生长因子 (TGF) β2 是 TGF-β 超家族的成员,调节多种细胞表型。与 TGF-β1 和 TGF-β3 类似,TGF-β2 通过 I 型和 II 型丝氨酸-苏氨酸激酶受体发出信号,并通过 SMAD 家族蛋白激活信号转导,从而调节细胞增殖、分化、伤口愈合、凋亡和代谢等多种功能 (de Caestecker; Massague; Zuniga et al.)。TGF-β2 在许多发育过程中发挥重要作用;例如,TGF-β2 缺失的小鼠在心脏、肺、颅面、肢体、眼、耳和泌尿生殖系统的发育中表现出缺陷 (Dunker & Kreiglstein)。
亚型
细胞因子,生长因子
细胞类型
气道细胞,间充质细胞,PSC衍生,间充质干/祖细胞
种属
人
研究领域
呼吸系统研究,干细胞生物学
纯度
≥ 95 %
(A) The biological activity of Human Recombinant TGF-beta 2 was tested by its ability to promote the proliferation of mouse HT-2 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.2 ng/mL. (B) 5 μg of Human Recombinant TGF-beta 2 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant TGF-beta 2 has a predicted molecular mass of 12.7 kDa.
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Species | Human |
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Purity | ≥ 95% |
转化生长因子β1
转化生长因子α
转化生长因子β 3
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