重组人TGF - β 2

转化生长因子β 2

产品号 #(选择产品)

产品号 #78174_C

转化生长因子β 2

总览

转化生长因子 (TGF) β2 是 TGF-β 超家族的成员,调节多种细胞表型。与 TGF-β1 和 TGF-β3 类似,TGF-β2 通过 I 型和 II 型丝氨酸-苏氨酸激酶受体发出信号,并通过 SMAD 家族蛋白激活信号转导,从而调节细胞增殖、分化、伤口愈合、凋亡和代谢等多种功能 (de Caestecker; Massague; Zuniga et al.)。TGF-β2 在许多发育过程中发挥重要作用;例如,TGF-β2 缺失的小鼠在心脏、肺、颅面、肢体、眼、耳和泌尿生殖系统的发育中表现出缺陷 (Dunker & Kreiglstein)。

亚型
细胞因子,生长因子
 
细胞类型
气道细胞,间充质细胞,PSC衍生,间充质干/祖细胞
 
种属

 
研究领域
呼吸系统研究,干细胞生物学
 
纯度
≥ 95 %
 

Data Figures

(A) The biological activity of Human Recombinant TGF-beta 2 was tested by its ability to promote the proliferation of mouse HT-2 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.2 ng/mL. (B) 5 μg of Human Recombinant TGF-beta 2 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant TGF-beta 2 has a predicted molecular mass of 12.7 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78174.1, 78174
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78174.1, 78174
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

更多信息

更多信息
Species Human
Purity ≥ 95%
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