产品号 #78053_C
Interleukin 7
概述
Interleukin 7 (IL-7) is a member of the Type I cytokine family that is critical for T and B cell development and survival. It is produced by non-hematopoietic cells in the thymus, lymphoid organs, and by bone marrow stromal cells (Lundström et al.). IL-7 binds to a receptor (IL-7R) composed of common gamma chain and IL-7Ra (CD127) and signals through the JAK/STAT and PI3K pathways. IL-7 regulates the survival of naïve and memory CD4+ and CD8+ T cells, γδ T cells, NK T cells, innate lymphoid cells, and T regulatory cells (Carrette & Surh). Although a deficiency in IL-7R still permits the generation of normal numbers of peripheral B cells in humans, stimulation of human B cell precursors with IL-7 could promote STAT-5-dependent proliferation and survival in vitro (Clark et al.; Corfe & Paige).
Subtype
Cytokines
Alternative Names
<p>Interleukin-7, LP-1, Lymphopoietin 1, Pre-B cell factor<br></p>
Cell Type
Hematopoietic Stem and Progenitor Cells, Lymphocytes
Species
Human
Area of Interest
Immunology, Stem Cell Biology
Purity
≥ 95%
Data Figures
Figure 1. Biological Activity and Molecular Weight of Human Recombinant IL-7
(A) The biological activity of Human Recombinant IL-7 was tested by its ability to promote the proliferation of PHA-stimulated PBMCs. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the above example is ≤ 0.5 ng/mL. (B) 1 μg of Human Recombinant IL-7 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-7 has a predicted molecular mass of 17.5 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet 1 Product Name
Human Recombinant IL-7 Catalog #
78053.3, 78053.1, 78053 Lot #
1000171777 and higher Language
English Document Type
Product Information Sheet 2 Product Name
Human Recombinant IL-7 Catalog #
78053.3, 78053.1, 78053 Lot #
1000171776 and lower Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant IL-7 Catalog #
78053.3, 78053.1, 78053 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Hematopoietic Stem and Progenitor Cell Research
Workflow Stages for Total Lymphocyte Research
Workflow Stages for T Cell Research
Workflow Stages for T Cell Engineering
Workflow Stages for B Cell Research
Resources and Publications
Educational Materials (3)
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