产品号 #78053_C
白介素7
白介素7 (IL-7)是I型细胞因子家族的一员,对T细胞和B细胞的发育和存活至关重要。它由胸腺、淋巴器官和骨髓基质细胞中的非造血细胞产生(Lundström et al.)。IL-7结合由共同γ链和IL-7Ra (CD127)组成的受体(IL-7R),并通过JAK/STAT和PI3K通路发出信号。IL-7调节naïve和记忆CD4+和CD8+ T细胞、γδ T细胞、NK T细胞、先天淋巴样细胞和T调节细胞的存活(Carrette & Surh)。尽管缺乏IL-7R仍然允许人产生正常数量的外周B细胞,但用IL-7刺激人B细胞前体可以促进STAT -5依赖性的增殖和体外存活(Clark et al.; Corfe & Paige)。
亚型
细胞因子
别名
白细胞介素-7;LP-1;淋巴造血因子 1;前 B 细胞因子
细胞类型
造血干/祖细胞,淋巴细胞
种属
人
研究领域
免疫,干细胞生物学
纯度
≥ 95 %
Figure 1. Biological Activity and Molecular Weight of Human Recombinant IL-7
(A) The biological activity of Human Recombinant IL-7 was tested by its ability to promote the proliferation of PHA-stimulated PBMCs. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the above example is ≤ 0.5 ng/mL. (B) 1 μg of Human Recombinant IL-7 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-7 has a predicted molecular mass of 17.5 kDa.
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Species | Human |
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Alternative Names | Interleukin-7, LP-1, Lymphopoietin 1, Pre-B cell factor |
Purity | ≥ 95% |
小鼠单克隆IgG2b抗体,抗人、恒河猴、食蟹猴CD4
小鼠单克隆IgG1抗体,抗人、恒河猴、食蟹猴CD8a
白介素7
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