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重组人IL-7

白介素7
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产品号 #78053_C

白介素7

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总览

白介素7 （IL-7）是I型细胞因子家族的一员，对T细胞和B细胞的发育和存活至关重要。它由胸腺、淋巴器官和骨髓基质细胞中的非造血细胞产生（Lundström et al.）。IL-7结合由共同γ链和IL-7Ra （CD127）组成的受体（IL-7R），并通过JAK/STAT和PI3K通路发出信号。IL-7调节naïve和记忆CD4+和CD8+ T细胞、γδ T细胞、NK T细胞、先天淋巴样细胞和T调节细胞的存活（Carrette & Surh）。尽管缺乏IL-7R仍然允许人产生正常数量的外周B细胞，但用IL-7刺激人B细胞前体可以促进STAT -5依赖性的增殖和体外存活(Clark et al.; Corfe & Paige)。

亚型
细胞因子
 
别名
白细胞介素-7；LP-1；淋巴造血因子 1；前 B 细胞因子
 
细胞类型
造血干/祖细胞，淋巴细胞
 
种属
人
 
研究领域
免疫，干细胞生物学
 
纯度
≥ 95 %
 

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Data Figures

78053_C_DA0031_data_01

Figure 1. Biological Activity and Molecular Weight of Human Recombinant IL-7

(A) The biological activity of Human Recombinant IL-7 was tested by its ability to promote the proliferation of PHA-stimulated PBMCs. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the above example is ≤ 0.5 ng/mL. (B) 1 μg of Human Recombinant IL-7 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-7 has a predicted molecular mass of 17.5 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet 1
Product Name
Human Recombinant IL-7
Catalog #
78053.3, 78053.1, 78053
Lot #
1000171777 and higher
Language
English
Document Type
Product Information Sheet 2
Product Name
Human Recombinant IL-7
Catalog #
78053.3, 78053.1, 78053
Lot #
1000171776 and lower
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-7
Catalog #
78053.3, 78053.1, 78053
Lot #
All
Language
English

Resources and Publications

Educational Materials (3)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Tools for Your Immunology Research
Brochure
Tools for Your Immunology Research
Human Immune Cytokines
Wallchart
Human Immune Cytokines

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更多信息
Species Human
Alternative Names Interleukin-7, LP-1, Lymphopoietin 1, Pre-B cell factor
Purity ≥ 95%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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