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重组小鼠IL-7

白介素7
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产品号 #78054_C

白介素7

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总览
实验数据
产品说明书及文档
应用领域
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总览

白介素7 （IL-7）是I型细胞因子家族的一员，对T细胞和B细胞的发育和存活至关重要。它由胸腺、淋巴器官和骨髓基质细胞中的非造血细胞产生（Lundström et al.）。IL-7结合由共同γ链和IL-7Ra （CD127）组成的受体，并通过JAK/STAT和PI3K通路发出信号。IL-7调节naïve和记忆CD4+和CD8+ T细胞、γδ T细胞、NK T细胞、先天淋巴样细胞和T调节细胞的存活（Carrette & Surh），并在B细胞发育过程中提供促进存活、增殖和分化的信号(Clark et al.; Corfe & Paige)。

亚型
细胞因子
 
细胞类型
造血干/祖细胞，淋巴细胞
 
种属
小鼠
 
研究领域
免疫，干细胞生物学
 
纯度
≥ 95 %
 

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Data Figures

(A) The biological activity of Mouse Recombinant IL-7 was tested by its ability to promote the proliferation of 2E8 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.4 ng/mL.
(B) 5 μg of Mouse Recombinant IL-7 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-7 has a predicted molecular mass of 15 kDa but migrates to an apparent molecular mass of ~24 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Mouse Recombinant IL-7
Catalog #
78054.1, 78054
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant IL-7
Catalog #
78054.1, 78054
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (3)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Tools for Your Immunology Research
Brochure
Tools for Your Immunology Research
Human Immune Cytokines
Wallchart
Human Immune Cytokines

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Species Mouse
Purity ≥ 95%
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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