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人重组IL-6， ACF

白细胞介素6，不含动物成分
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产品号 #78148_C

白细胞介素6，不含动物成分

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实验数据
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总览

白细胞介素6（IL-6）是一种多效生长因子，在免疫调节、造血和肿瘤发生等方面具有广泛的生物活性。IL-6由多种细胞类型产生，包括T细胞、B细胞、单核细胞和巨噬细胞、成纤维细胞、肝细胞、血管内皮细胞和各种肿瘤细胞系。IL-6单独或与IL-2和干扰素-γ等其他因子联合作用时，可刺激B细胞、T细胞和杂交瘤细胞的增殖（Hirano et al.; Mihara et al.; Tanaka et al）。IL-6与IL-3、GM-CSF和SCF等细胞因子联合使用，已被证明能促进体外造血祖细胞的增殖和分化。IL-6通过细胞表面I型细胞因子受体复合物发出信号，该复合物由结合配体的IL-6α (CD126) 和信号转导的gp130亚基组成。IL-6与其受体系统的结合包括激活JAK/STAT信号通路（Mihara et al.; Peters et al.; Tanaka et al.）。本产品不含动物成分。

亚型
细胞因子
 
别名
B 细胞分化因子；BSF-2；IFN-β2；白细胞介素-6
 
细胞类型
气道细胞，B 细胞，造血干/祖细胞，肠道细胞，淋巴细胞，T 细胞
 
种属
人
 
研究领域
上皮细胞研究，免疫，神经科学，干细胞生物学
 
制剂类别
Animal Component-Free
 
纯度
≥ 97 %
 

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Data Figures

(A) The biological activity of Human Recombinant IL-6, ACF was tested by its ability to promote the proliferation of B9 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is 3.31 pg/mL.
(B) 1 μg of Human Recombinant IL-6, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-6, ACF has a predicted molecular mass of 21 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant IL-6, ACF
Catalog #
78148, 78148.1, 78148.2
Lot #
1000123421 or higher
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-6, ACF
Catalog #
78148, 78148.1, 78148.2
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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Species Human
Formulation Category Animal Component-Free
Alternative Names B cell differentiation factor, BSF-2, IFN-β2, Interleukin-6
Purity ≥ 97%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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