产品号 #78148_C
白细胞介素6,不含动物成分
白细胞介素6(IL-6)是一种多效生长因子,在免疫调节、造血和肿瘤发生等方面具有广泛的生物活性。IL-6由多种细胞类型产生,包括T细胞、B细胞、单核细胞和巨噬细胞、成纤维细胞、肝细胞、血管内皮细胞和各种肿瘤细胞系。IL-6单独或与IL-2和干扰素-γ等其他因子联合作用时,可刺激B细胞、T细胞和杂交瘤细胞的增殖(Hirano et al.; Mihara et al.; Tanaka et al)。IL-6与IL-3、GM-CSF和SCF等细胞因子联合使用,已被证明能促进体外造血祖细胞的增殖和分化。IL-6通过细胞表面I型细胞因子受体复合物发出信号,该复合物由结合配体的IL-6α (CD126) 和信号转导的gp130亚基组成。IL-6与其受体系统的结合包括激活JAK/STAT信号通路(Mihara et al.; Peters et al.; Tanaka et al.)。本产品不含动物成分。
亚型
细胞因子
别名
B 细胞分化因子;BSF-2;IFN-β2;白细胞介素-6
细胞类型
气道细胞,B 细胞,造血干/祖细胞,肠道细胞,淋巴细胞,T 细胞
种属
人
研究领域
上皮细胞研究,免疫,神经科学,干细胞生物学
制剂类别
Animal Component-Free
纯度
≥ 97 %
(A) The biological activity of Human Recombinant IL-6, ACF was tested by its ability to promote the proliferation of B9 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is 3.31 pg/mL.
(B) 1 μg of Human Recombinant IL-6, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-6, ACF has a predicted molecular mass of 21 kDa.
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
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Species | Human |
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Formulation Category | Animal Component-Free |
Alternative Names | B cell differentiation factor, BSF-2, IFN-β2, Interleukin-6 |
Purity | ≥ 97% |
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