产品号 #78145_C
白细胞介素2,不含动物成分
白细胞介素2(IL-2)是一种单体细胞因子,最初被鉴定为T细胞生长因子(Gaffen & Liu)。它与由CD25、CD122和CD132组成的异三聚体受体结合。结合后,它会激活JAK3、STAT5和AKT依赖的信号通路,从而促进细胞增殖和存活(Ma et al.)。大多数IL-2由活化的CD4+和CD8+ T细胞分泌,而B细胞和树突状细胞也产生少量IL-2。IL-2会下调胸腺发育过程中的免疫反应以防止自身免疫,影响CD4+CD25+调节性T细胞的发育,并影响滤泡辅助性T细胞的发育。IL-2也会通过抑制Th17分化来控制炎症(Banchereau et al.)。血清中高水平的IL-2与硬皮病、类风湿关节炎、胃癌和非小细胞肺癌的发展有关,尽管目前还没有已知的疾病可以直接归因于IL-2缺乏或过量(Gaffen & Liu)。
亚型
细胞因子
别名
阿德福韦;白细胞介素-2;T 细胞生长因子;TCGF
细胞类型
造血干/祖细胞,NK 细胞,T 细胞,T 细胞,CD4+,T 细胞,CD8+
种属
人
研究领域
免疫,干细胞生物学
制剂类别
Animal Component-Free
纯度
≥ 97 %
(A) The biological activity of Human Recombinant IL-2, ACF was tested by its ability to promote the proliferation of CTLL-2 cells. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is 1.99 ng/mL. (B) 1 μg of Human Recombinant IL-2, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.
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Species | Human |
---|---|
Formulation Category | Animal Component-Free |
Alternative Names | Aldesleukin, Interleukin-2, T cell growth factor, TCGF |
Purity | ≥ 97% |
人T细胞激活扩增试剂
用于T细胞扩增的无血清和无异种成分培养基
白介素2
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