人重组IL-2, ACF

白细胞介素2,不含动物成分

产品号 #(选择产品)

产品号 #78145_C

白细胞介素2,不含动物成分

总览

白细胞介素2(IL-2)是一种单体细胞因子,最初被鉴定为T细胞生长因子(Gaffen & Liu)。它与由CD25、CD122和CD132组成的异三聚体受体结合。结合后,它会激活JAK3、STAT5和AKT依赖的信号通路,从而促进细胞增殖和存活(Ma et al.)。大多数IL-2由活化的CD4+和CD8+ T细胞分泌,而B细胞和树突状细胞也产生少量IL-2。IL-2会下调胸腺发育过程中的免疫反应以防止自身免疫,影响CD4+CD25+调节性T细胞的发育,并影响滤泡辅助性T细胞的发育。IL-2也会通过抑制Th17分化来控制炎症(Banchereau et al.)。血清中高水平的IL-2与硬皮病、类风湿关节炎、胃癌和非小细胞肺癌的发展有关,尽管目前还没有已知的疾病可以直接归因于IL-2缺乏或过量(Gaffen & Liu)。

亚型
细胞因子
 
别名
阿德福韦;白细胞介素-2;T 细胞生长因子;TCGF
 
细胞类型
造血干/祖细胞,NK 细胞,T 细胞,T 细胞,CD4+,T 细胞,CD8+
 
种属

 
研究领域
免疫,干细胞生物学
 
制剂类别
Animal Component-Free
 
纯度
≥ 97 %
 

Data Figures

(A) The biological activity of Human Recombinant IL-2, ACF was tested by its ability to promote the proliferation of CTLL-2 cells. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is 1.99 ng/mL. (B) 1 μg of Human Recombinant IL-2, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78145.1, 78145.2, 78145
Lot #
1000123632 or lower
Language
English
Catalog #
78145.1, 78145.2, 78145
Lot #
1000123633 or higher
Language
English
Document Type
Safety Data Sheet
Catalog #
78145.1, 78145.2, 78145
Lot #
All
Language
English

更多信息

更多信息
Species Human
Formulation Category Animal Component-Free
Alternative Names Aldesleukin, Interleukin-2, T cell growth factor, TCGF
Purity ≥ 97%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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