产品号 #78050_C
Interleukin 6
概述
Interleukin 6 (IL-6) is a pleiotropic growth factor with the wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Hirano et al.; Mihara et al.; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of JAK/STAT signaling pathway (Mihara et al.; Peters et al.; Tanaka et al.).
Subtype
Cytokines
Cell Type
Airway Cells, B Cells, Hematopoietic Stem and Progenitor Cells, Intestinal Cells, Lymphocytes, Neurons, Pluripotent Stem Cells, T Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Immunology, Neuroscience, Stem Cell Biology
Purity
≥ 97%
Data Figures
(A) The biological activity of Human Recombinant IL-6 was tested by its ability to promote the proliferation of B9 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 3.31 pg/mL.
(B) 1 μg of Human Recombinant IL-6 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-6 has a predicted molecular mass of 21 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet 1 Product Name
Human Recombinant IL-6 Catalog #
78050, 78050.2, 78050.1 Lot #
1000122298 or higher Language
English Document Type
Product Information Sheet 2 Product Name
Human Recombinant IL-6 Catalog #
78050, 78050.2, 78050.1 Lot #
1000122297 or lower Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant IL-6 Catalog #
78050, 78050.2, 78050.1 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Airway Epithelial Cell Research
Workflow Stages for Dendritic Cell Research
Workflow Stages for Hematopoietic Stem and Progenitor Cell Research
Workflow Stages for hPSC-Derived Mesoderm Cell Research
Workflow Stages for Total Lymphocyte Research
Workflow Stages for Hematopoietic Cell Therapy Development
Resources and Publications
Educational Materials (4)
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