产品号 #78050_C
白介素6
白介素6 (IL-6)是一种多效生长因子,在免疫调节、造血和肿瘤发生等人方面具有广泛的生物活性。IL-6由多种细胞类型产生,包括T细胞、B细胞、单核细胞和巨噬细胞、成纤维细胞、肝细胞、血管内皮细胞和各种肿瘤细胞系。IL-6单独或与其他因子如IL-2和干扰素-γ联合作用时,可刺激B细胞、T细胞和杂交瘤细胞的增殖(Hirano et al.; Mihara et al.; Tanaka et al)。与IL-3、GM-CSF和SCF等人细胞因子联合使用,IL-6已被证明能促进体外造血祖细胞增殖和分化。IL-6通过由配体结合IL-6α (CD126)和信号转导gp130亚基组成的细胞表面I型细胞因子受体复合物发出信号。IL-6与其受体系统的结合包括激活JAK/STAT信号通路(Mihara et al.; Peters et al.; Tanaka et al.)。
亚型
细胞因子
细胞类型
气道细胞,B 细胞,造血干/祖细胞,肠道细胞,淋巴细胞,神经元,多能干细胞,T 细胞
种属
人
研究领域
上皮细胞研究,免疫,神经科学,干细胞生物学
纯度
≥ 97 %
(A) The biological activity of Human Recombinant IL-6 was tested by its ability to promote the proliferation of B9 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 3.31 pg/mL.
(B) 1 μg of Human Recombinant IL-6 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-6 has a predicted molecular mass of 21 kDa.
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Species | Human |
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Purity | ≥ 97% |
白介素2
白介素4
白介素6
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