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人重组IL-3， ACF

白细胞介素3，不含动物成分
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产品号 #78146_C

白细胞介素3，不含动物成分

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白细胞介素3（IL-3）是一种物种特异性的多效性细胞因子，可促进多能造血干细胞和谱系定向祖细胞的存活和增殖，并促进其分化为大多数谱系的成熟细胞，包括嗜碱性粒细胞、中性粒细胞、嗜酸性粒细胞、巨噬细胞、树突状细胞、红细胞和巨核细胞(Yang et al.; Dorssers et al.; Broughton et al.)。IL-3由活化的T细胞产生，通过促进嗜碱性粒细胞和嗜酸性粒细胞分泌组胺、IL-4和IL-6等炎症因子，在炎症和过敏中发挥生理作用（Broughton et al.）。IL-3受体由一个独特的α亚基（CD123）以及一个与IL-5和GM-CSF受体共享的β共同亚基（βc或CD131）组成，是这些细胞因子的主要信号转导亚基。IL-3与异二聚体受体结合可激活JAK/STAT、MAPK和PI3K信号通路（Woodcock et al.）。本产品不含动物成分。
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Data Figures

(A) The biological activity of Human Recombinant IL-3, ACF was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.244 ng/mL.
(B) 1 μg of Human Recombinant IL-3, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet 1
Product Name
Human Recombinant IL-3, ACF
Catalog #
78146.2, 78146, 78146.1
Lot #
1000122436 or higher
Language
English
Document Type
Product Information Sheet 2
Product Name
Human Recombinant IL-3, ACF
Catalog #
78146.2, 78146, 78146.1
Lot #
1000122435 or lower
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-3, ACF
Catalog #
78146.2, 78146, 78146.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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Workflow Stages

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Species Human
Formulation Category Animal Component-Free
Alternative Names FGFA, Fibroblast growth factor-10, Keratinocyte growth factor-2
Purity ≥ 97%
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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