产品号 #78042_C
白介素3
白介素 3 (IL-3) 是一种物种特异性的多效性细胞因子,可促进多能造血干细胞和谱系定型祖细胞的存活和增殖,并促进其分化为大多数谱系的成熟细胞,包括肥大细胞、嗜碱性粒细胞、中性粒细胞、嗜酸性粒细胞、巨噬细胞、树突状细胞、红细胞和巨核细胞 (Fung et al.; Metcalf et al.; Broughton et al.)。IL-3 由活化的 T 细胞产生,通过促进肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞分泌组胺、IL-4 和 IL-6 等炎症介质,在炎症和过敏中发挥生理作用。小鼠 IL-3 受体由一个独特的 α 亚基(CD123)和两个 β 亚基组成,其中一个 β 亚基特异性针对 IL-3(βIL-3),另一个 β 亚基与 IL-5 和 GM-CSF 受体共用(β 共同链,βc 或 CD131)。IL-3 与含有 α 亚基和任一 β 亚基的异二聚体受体结合,可激活 JAK/STAT、MAPK 和 PI3K 信号通路(Scott & Begley)。
亚型
细胞因子
细胞类型
造血干/祖细胞,中胚层,PSC衍生,多能干细胞
种属
小鼠
研究领域
干细胞生物学
纯度
≥ 95 %
(A) The biological activity of Mouse Recombinant IL-3 was tested by its ability to promote the proliferation of Ba/F3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 2 - 3 pg/mL.
(B) 1 μg of Mouse Recombinant IL-3 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-3 has a predicted molecular mass of 15.2 kDa.
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
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Species | Mouse |
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Purity | ≥ 95% |
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