产品号 #78038_C
Interleukin 22
概述
Interleukin 22 (IL-22) is a class 2 α-helical cytokine that signals through the class 2 cytokine receptor and activates the JAK/STAT pathway. IL-22 is secreted by Th1, Th2, Tc22, and γδ T cells, dendritic, mast and NK cells. It stimulates expression of antimicrobial peptides from epithelial cells, thus hindering bacterial infections. Depending on the interactions with other cytokines, IL-22 can either promote inflammation or prevent tissue destruction by regulating host defense and tissue homeostasis at barrier surfaces (Sonnenberg et al.).
Subtype
Cytokines
Alternative Names
<p>IL-TIF, Interleukin-22</p>
Cell Type
Airway Cells, Hepatic Cells, Intestinal Cells, Keratinocytes, T Cells, T Cells, CD4+, T Cells, CD8+
Species
Human
Area of Interest
Epithelial Cell Biology, Immunology
Purity
> 98%
Data Figures
(A) The biological activity of Human Recombinant IL-22 was tested by its ability to produce IL-10 in COLO 205 cells. IL-10 secretion was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 1 ng/mL.
(B) 2 μg of Human Recombinant IL-22 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-22 has a predicted molecular mass of 16.9 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Human Recombinant IL-22 Catalog #
78038 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Human Recombinant IL-22 Catalog #
78038 Lot #
All Language
English Resources and Publications
Educational Materials (3)
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