重组人 IL-22

白介素22

产品号 #(选择产品)

产品号 #78038_C

白介素22

总览

白介素 22 (IL-22) 是一种 2 类 α-螺旋细胞因子,通过 2 类细胞因子受体发出信号并激活 JAK/STAT 通路。IL-22 由 Th1、Th2、Tc22 和 γδ T 细胞、树突状细胞、肥大细胞和 NK 细胞分泌。它刺激上皮细胞表达抗菌肽,从而抑制细菌感染。根据与其他细胞因子的相互作用,IL-22 可以通过调节宿主防御和屏障表面的组织稳态来促进炎症或防止组织破坏(Sonnenberg et al.)。

亚型
细胞因子
 
别名
IL-TIF;白细胞介素-22
 
细胞类型
气道细胞,肝细胞,肠道细胞,角质形成细胞,T 细胞,T 细胞,CD4+,T 细胞,CD8+
 
种属

 
研究领域
上皮细胞研究,免疫
 
纯度
> 98%
 

Data Figures

(A) The biological activity of Human Recombinant IL-22 was tested by its ability to produce IL-10 in COLO 205 cells. IL-10 secretion was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 1 ng/mL.
(B) 2 μg of Human Recombinant IL-22 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-22 has a predicted molecular mass of 16.9 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78038
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78038
Lot #
All
Language
English

Resources and Publications

Educational Materials (3)

更多信息

更多信息
Species Human
Alternative Names IL-TIF, Interleukin-22
Purity > 98%
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