产品号 #60143_C
兔多克隆抗体,抗人、小鼠SHIP2
SHIP2是一种分子量为145 kDa的SHIP相关蛋白,在造血系统和非造血系统细胞中均有表达。与含有SH2结构域的肌醇磷酸酶(SHIP)一样,在细胞因子、生长因子、趋化因子和免疫受体的刺激下,SHIP2被酪氨酸磷酸化并与适配蛋白Shc结合。该蛋白通过水解磷脂酰肌醇3激酶(PI3K)产生的关键第二信使PI-3,4,5-P3(PIP3)生成PI-3,4-P2,从而负向调控PI3K信号通路。该抗体可特异性识别小鼠和人源全长145 kDa的SHIP2蛋白。
亚型
一抗
靶抗原
SHIP2
别名
肌醇多磷酸磷酸酶样1,INPPL1,OPSMD
活性物种
人,小鼠
偶联
未偶联的
宿主物种
兔
细胞类型
粒细胞及其亚群,淋巴细胞,髓系细胞
种属
小鼠
应用
免疫印迹,免疫沉淀
研究领域
免疫
克隆
Not applicable
基因编号
3636 (human),16332 (mouse)
同种型
Not applicable
Western blot analysis of total cell lysates (TCL) from human TF-1 cells, mouse WEHI-231 B cells, and mouse bone marrow derived mast cells (BMMCs) of SHIP +/+ and SHIP -/- mice with Anti-SHIP2 Antibody, Polyclonal (1:1000 dilution). The last two lanes represent anti-SHIP2 immunoprecipitates (IP) of 1 x 107 TF-1 cells and WEHI-231 B cells, respectively. SHIP2 has a predicted molecular mass of 145 kDa.
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
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Species | Mouse |
---|---|
Clone | Not applicable |
Gene Id | 3636 (human), 16332 (mouse) |
Alternative Names | Inositol polyphosphate phosphatase like 1, INPPL1, OPSMD |
Isotype | Not applicable |
山羊多克隆IgG (H+L)抗体,抗兔
兔多克隆抗体,抗小鼠SHIP
兔多克隆抗体,抗人、小鼠磷酸化SHIP
兔多克隆抗体,抗人、小鼠SHIP
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