产品号 #60104_C
Hamster (Armenian) monoclonal IgG2 antibody against mouse T Cell receptor gamma/delta
概述
The GL3 antibody reacts with the δ chain of the murine T cell receptor γ/δ (TCRγ/δ or TCR gamma/delta), a subtype of the TCR involved in the recognition of both peptide and lipid antigens. TCRγ/δ comprises a heterodimer (~ 80 kDa in humans) of disulfide-linked γ and δ subunits that associates with CD3 on the cell surface. It is a member of the immunoglobulin superfamily. TCRγ/δ is expressed on a subpopulation of T cells in the circulation but may be found on up to 50% of the T cells in epithelial cell-rich tissues. These cells have roles in oral and tumor-associated tolerance as well as autoimmune disease and have been described as a link between the adaptive and innate immune responses. Once activated, they secrete effector cytokines in a subtype- and context-specific manner. Most γ/δ T cells are CD4-/CD8-, though some express CD8. The GL3 antibody recognizes an epitope in the constant region of the δ chain and can reportedly activate TCRγ/δ+ cells.
Subtype
Primary Antibodies
Target Antigen
T Cell Receptor Gamma/Delta
Alternative Names
Gamma/Delta TCR , gdTCR, TCRgd, TCR γ/δ, T cell receptor delta chain, T cell receptor gamma chain, T cell receptor γ/δ, T3D, T3G
Reactive Species
Mouse
Conjugation
Alexa Fluor 488, APC, Biotin, FITC, PE, Unconjugated
Host Species
Hamster
Cell Type
T Cells, T Cells, Other Subsets
Species
Mouse
Application
Cell Isolation, Depletion, Flow Cytometry, Functional Assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Neutralization and Blocking
Area of Interest
Immunology
Clone
GL3
Gene ID
110066/110067
Isotype
IgG2, kappa
Data Figures
Figure 1. Data for Unconjugated
(A) Flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, followed by an anti-hamster (Armenian) IgG antibody, FITC and Anti-Mouse CD3e Antibody, Clone 145-2C11, APC (Catalog #60015AZ).
Figure 2. Data for Alexa Fluor® 488-Conjugated
(A) Flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, Alexa Fluor® 488 and Anti-Mouse CD3e Antibody, Clone 145-2C11, APC (Catalog #60015AZ).
Figure 3. Data for APC-Conjugated
(A) Flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, APC and Anti-Mouse CD3e Antibody, Clone 145-2C11, PE (Catalog #60015PE).
Figure 4. Data for Biotin-Conjugated
(A) Flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, Biotin followed by streptavidin (SAV) APC and Anti-Mouse CD3e Antibody, Clone 145-2C11, PE (Catalog #60015PE).
Figure 5. Data for FITC-Conjugated
(A) Flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, FITC and Anti-Mouse CD3e Antibody, Clone 145-2C11, APC (Catalog #60015AZ).
Figure 6. Data for PE-Conjugated
(A) Flow cytometry analysis of C57BL/6 mouse lymph node cells labeled with Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, PE and Anti-Mouse CD3e Antibody, Clone 145-2C11, APC (Catalog #60015AZ).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, APC Catalog #
60104AZ, 60104AZ.1 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, FITC Catalog #
60104FI.1 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, PE Catalog #
60104PE, 60104PE.1 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3 Catalog #
60104 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, APC Catalog #
60104AZ, 60104AZ.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, FITC Catalog #
60104FI.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3, PE Catalog #
60104PE, 60104PE.1 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse TCR Gamma/Delta Antibody, Clone GL3 Catalog #
60104 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Resources and Publications
Educational Materials (2)
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Legal Statement: Alexa Fluor is a registered trademark of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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