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抗小鼠CD3e抗体，克隆145-2C11

亚美尼亚仓鼠单克隆IgG1抗体，抗小鼠CD3e
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产品号 #（选择产品）

产品号 #60015_C

亚美尼亚仓鼠单克隆IgG1抗体，抗小鼠CD3e

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总览
实验数据
产品说明书及文档
应用领域
相关材料与文献
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总览

145-2C11抗体识别小鼠T细胞受体（TCR）/CD3复合物的~ 20kda CD3ε亚基，该亚基在循环成熟T细胞和NKT细胞表面表达，在胸腺细胞上呈可变表达。大多数T细胞瘤也表达CD3。CD3复合物由CD3γ、δ、ε、η和ζ亚基组合而成，与TCR非共价结合，参与将抗原识别信号转导到T细胞的胞质中，并调节TCR的细胞表面表达。TCR介导的T细胞激活涉及CD3亚基的胞质尾部，CD3 亚基是结构相关的 1 型跨膜蛋白，属于免疫球蛋白超家族。CD3亚基的突变与多种免疫缺陷疾病有关，包括严重的联合免疫缺陷（SCID）。145-2C11抗体已被用于体外功能学（阻断和激活）实验，并据报导可阻断抗体克隆17A2的结合。145-2C11抗体不推荐用于福尔马林固定、石蜡包埋切片。

该抗体克隆已被验证可用于评估EasySep™试剂盒（包括EasySep™小鼠T细胞分选试剂盒（产品号 #19851）和EasySep™小鼠CD90.2正选试剂盒II（产品号#18951））分选的细胞纯度。

亚型
一抗
 
靶抗原
CD3e
 
别名
CD3，CD3epsilon，T3
 
活性物种
小鼠
 
偶联
Alexa Fluor 488，APC，Biotin 或 生物素，FITC，PE，PerCP-Cyanine5.5，未偶联的
 
宿主物种
Hamster
 
细胞类型
T 细胞
 
种属
小鼠
 
应用
细胞分选，ELISAs，流式细胞术，功能学筛选，免疫细胞化学，免疫荧光，免疫组化，免疫沉淀，Western印迹
 
研究领域
免疫
 
克隆
145-2C11
 
基因编号
12501
 
同种型
IgG1，kappa
 

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Data Figures

Data for Alexa Fluor® 488-Conjugated

Figure 1. Data for Alexa Fluor® 488-Conjugated

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD3e Antibody, Clone 145-2C11, Alexa Fluor® 488 (filled histogram) or an Armenian hamster IgG Alexa Fluor® 488 isotype control antibody (solid line histogram).

Data for PE-Conjugated

Figure 2. Data for PE-Conjugated

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD3e Antibody, Clone 145-2C11, PE (filled histogram) or an Armenian hamster IgG PE isotype control antibody (solid line histogram).

Data for Unconjugated

Figure 3. Data for Unconjugated

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD3e Antibody, Clone 145-2C11, followed by an anti-hamster IgG antibody, FITC (filled histogram), or a hamster (Armenian) IgG isotype control antibody followed by an anti-hamster IgG antibody, FITC (solid line histogram).

Data for APC-Conjugated

Figure 4. Data for APC-Conjugated

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD3e Antibody, Clone 145-2C11, APC (filled histogram) or an Armenian hamster IgG APC isotype control antibody (solid line histogram).

Data for Biotin-Conjugated

Figure 5. Data for Biotin-Conjugated

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD3e Antibody, Clone 145-2C11, Biotin followed by streptavidin (SAV) APC (filled histogram) or an Armenian hamster IgG biotin isotype control antibody followed by SAV APC (solid line histogram).

Data for FITC-Conjugated

Figure 6. Data for FITC-Conjugated

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD3e Antibody, Clone 145-2C11, FITC (filled histogram) or an Armenian hamster IgG FITC isotype control antibody (solid line histogram).

Data for PerCP-Cy55-Conjugated

Figure 7. Data for PerCP-Cy55-Conjugated

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD3e Antibody, Clone 145-2C11, PerCP-Cy5.5 (filled histogram) or an Armenian hamster IgG isotype control antibody, PerCP-Cy5.5 (solid line histogram).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11, FITC
Catalog #
60015FI, 60015FI.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11, PerCP-Cy5.5
Catalog #
60015PS.1, 60015PS
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11, PE
Catalog #
60015PE, 60015PE.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11, Biotin
Catalog #
60015BT, 60015BT.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11
Catalog #
60015
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11, Alexa Fluor® 488
Catalog #
60015AD
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11, APC
Catalog #
60015AZ, 60015AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11, FITC
Catalog #
60015FI, 60015FI.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11, PerCP-Cy5.5
Catalog #
60015PS.1, 60015PS
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11, PE
Catalog #
60015PE, 60015PE.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11, Biotin
Catalog #
60015BT, 60015BT.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11
Catalog #
60015
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11, Alexa Fluor® 488
Catalog #
60015AD
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD3e Antibody, Clone 145-2C11, APC
Catalog #
60015AZ, 60015AZ.1
Lot #
All
Language
English

更多信息

更多信息
Species Mouse
Clone 145-2C11
Gene Id 12501
Alternative Names CD3, CD3epsilon, T3
Isotype IgG1, kappa
Legal Statement: Alexa Fluor is a registered trademark of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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