产品号 #100-1610_C
Hamster (Armenian) monoclonal antibody against mouse T cell receptor beta
概述
This monoclonal antibody (clone H57-597) reacts with the beta chain of mouse T cell receptor (TCR). TCR beta is a member of the immunoglobulin superfamily and together with the TCR alpha chain forms the alpha-beta TCR. TCR beta is expressed by thymocytes in a developmentally regulated manner and a majority of peripheral T cells. Small number of T cells express an alternative heteromer of gamma and delta protein chains, known as the gamma-delta TCR. TCR-CD3 complex in conjunction with co-receptors CD4 or CD8 enables the recognition and response to antigens attached to major histocompatibility complex (MHC) molecules on antigen-presenting cells. Crosslinking of the TCR complex with H57-597 induces activation and proliferation of T cells or apoptosis based on assay conditions. Use this recombinant monoclonal antibody in applications requiring detection of TCR beta, such as flow cytometry (FC), and the unconjugated antibody in Immunoperoxidase (IP), immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC), and FC.
The H57-597 antibody clone has been widely used as a phenotypic indicator for T cells expressing alpha-beta TCR. This antibody does not cross-react with cells expressing the gamma-delta TCR.
Subtype
Primary Antibodies
Target Antigen
TCR beta
Alternative Names
Tcrb, TCR-b chain, TCR beta, Tib
Reactive Species
Mouse
Conjugation
APC, FITC, PE, PerCP-Cyanine5.5, Unconjugated
Host Species
Hamster
Cell Type
T Cells
Species
Mouse
Application
Flow Cytometry
Area of Interest
Immunology
Clone
H57-597
Gene ID
21577
Isotype
Armenian hamster IgG
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Mouse TCR Beta Antibody, Clone H57-597, APC Catalog #
100-1611 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse TCR Beta Antibody, Clone H57-597, FITC Catalog #
100-1613 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse TCR Beta Antibody, Clone H57-597, PE Catalog #
100-1612 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse TCR Beta Antibody, Clone H57-597 Catalog #
100-1610 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse TCR Beta Antibody, Clone H57-597, APC Catalog #
100-1611 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse TCR Beta Antibody, Clone H57-597, FITC Catalog #
100-1613 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse TCR Beta Antibody, Clone H57-597, PE Catalog #
100-1612 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse TCR Beta Antibody, Clone H57-597 Catalog #
100-1610 Lot #
All Language
English Resources and Publications
Educational Materials (2)
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