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抗小鼠CD4抗体，克隆RM4-4

抗小鼠CD4的大鼠单克隆IgG2b抗体
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产品号 #60029_C

抗小鼠CD4的大鼠单克隆IgG2b抗体

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总览
实验数据
产品说明书及文档
应用领域
相关材料与文献
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总览

RM4-4抗体可特异性识别小鼠CD4。CD4是一种分子量约为55 kDa的单链1型跨膜糖蛋白，属于免疫球蛋白 (Ig) 超家族成员；CD4包含4个细胞外Ig样结构域。CD4在大多数胸腺细胞和T细胞亚群（T辅助性/诱导细胞）中表达水平相对较高，而在树突状细胞中表达水平较低。小鼠的单核细胞/巨噬细胞不表达CD4。CD4与MHC II的非多态性区域结合，并通过增强TCR与MHC II-抗原复合物结合的亲和力，在MHC II限制性抗原识别中作为T细胞受体（TCR）的共受体。CD4还通过其胞内结构域与胞质酪氨酸激酶（如Lck）的相互作用，将信号从TCR放大至细胞质。RM4-4抗体的结合不会阻断抗体克隆RM4-5或GK1.5的结合。

亚型
一抗
 
靶抗原
CD4
 
别名
L3T4，T4
 
活性物种
小鼠
 
偶联
APC，Biotin 或 生物素，FITC，PE，未偶联的
 
宿主物种
大鼠
 
细胞类型
T 细胞，T 细胞，CD4+，T 细胞，调节性细胞
 
种属
小鼠
 
应用
流式细胞术，功能学筛选
 
研究领域
免疫
 
克隆
RM4-4
 
基因编号
12504
 
同种型
IgG2b，kappa
 

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Data Figures

Data for Unconjugated

Figure 1. Data for Unconjugated

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD4 Antibody, Clone RM4-4, followed by a mouse anti-rat IgG2b antibody, FITC (filled histogram), or Rat IgG2b, kappa Isotype Control Antibody, Clone RTK4530 (Catalog #60077), followed by a mouse anti-rat IgG2b antibody, FITC (solid line histogram).

Data for APC-Conjugated

Figure 2. Data for APC-Conjugated

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD4 Antibody, Clone RM4-4, APC (filled histogram) or Rat IgG2b, kappa Isotype Control Antibody, Clone RTK4530, APC (Catalog #60077AZ) (solid line histogram).

Data for Biotin-Conjugated

Figure 3. Data for Biotin-Conjugated

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD4 Antibody, Clone RM4-4, Biotin, followed by streptavidin (SAV) APC (filled histogram), or Rat IgG2b, kappa Isotype Control Antibody, Clone RTK4530, Biotin (Catalog #60077BT), followed by SAV APC (solid line histogram).

Data for FITC-Conjugated

Figure 4. Data for FITC-Conjugated

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD4 Antibody, Clone RM4-4, FITC (filled histogram) or Rat IgG2b, kappa Isotype Control Antibody, Clone RTK4530, FITC (Catalog #60077FI) (solid line histogram).

Data for PE-Conjugated

Figure 5. Data for PE-Conjugated

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD4 Antibody, Clone RM4-4, PE (filled histogram) or Rat IgG2b, kappa Isotype Control Antibody, Clone RTK4530, PE (Catalog #60077PE) (solid line histogram).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD4 Antibody, Clone RM4-4, APC
Catalog #
60029AZ, 60029AZ.1
Lot #
All
Language
English
Document Type
Product Information Sheet 1
Product Name
Anti-Mouse CD4 Antibody, Clone RM4-4, Biotin
Catalog #
60029BT.1, 60029BT
Lot #
All
Language
English
Document Type
Product Information Sheet 2
Product Name
Anti-Mouse CD4 Antibody, Clone RM4-4, Biotin
Catalog #
60029BT.1, 60029BT
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD4 Antibody, Clone RM4-4, FITC
Catalog #
60029FI.1, 60029FI
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD4 Antibody, Clone RM4-4, PE
Catalog #
60029PE.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD4 Antibody, Clone RM4-4, APC
Catalog #
60029AZ, 60029AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD4 Antibody, Clone RM4-4, Biotin
Catalog #
60029BT.1, 60029BT
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD4 Antibody, Clone RM4-4, FITC
Catalog #
60029FI.1, 60029FI
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD4 Antibody, Clone RM4-4, PE
Catalog #
60029PE.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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更多信息
Species Mouse
Clone RM4-4
Gene Id 12504
Alternative Names L3T4, T4
Isotype IgG2b, kappa
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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