产品号 #100-1619_C
Rat monoclonal antibody against mouse IL-4
概述
This monoclonal antibody reacts with mouse interleukin-4 (IL-4), a 14 kDa cytokine that is expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. IL-4 is a lymphoid cell growth factor and signals through the IL-4 receptor alpha chain (IL-4Rα) upon binding. This causes the stimulation of activated B and T lymphocytes as well as the differentiation of B cells into plasma cells. Use this recombinant monoclonal antibody in applications requiring detection of IL-4, such as flow cytometry (FC), and the unconjugated antibody in immunocytochemistry (ICC), immunohistochemistry - frozen sections (IHC-F), and FC.
IL-4 has the capability to attach and transmit signals through three different cell surface receptors: CD124, CD124 in combination with the common gamma chain (type I complex), or CD124 combined with CD213a1 (type II complex). Signal transducer and activator of transcription 6 (STAT6) has been shown to play an important role in mediating the immune regulatory signal of IL-4. IL-4 has been shown to play a role in normal wound healing and the development of allergic inflammation and asthma.
Subtype
Primary Antibodies
Target Antigen
IL-4
Alternative Names
B cell growth factor 1, B cell IgG differentiation factor, B cell stimulatory factor 1 (BSF-1), IGG1 induction factor, interleukin-4, lymphocyte stimulatory factor 1
Reactive Species
Mouse
Conjugation
APC, PE, Unconjugated
Host Species
Rat
Cell Type
Myeloid Cells, T Cells
Species
Mouse
Application
Flow Cytometry
Area of Interest
Immunology
Clone
11B11
Gene ID
16189
Isotype
IgG1, kappa
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Mouse IL-4 Antibody, Clone 11B11, APC Catalog #
100-1620 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse IL-4 Antibody, Clone 11B11, PE Catalog #
100-1619 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse IL-4 Antibody, Clone 11B11 Catalog #
100-1621 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse IL-4 Antibody, Clone 11B11, APC Catalog #
100-1620 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse IL-4 Antibody, Clone 11B11, PE Catalog #
100-1619 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse IL-4 Antibody, Clone 11B11 Catalog #
100-1621 Lot #
All Language
English Resources and Publications
Educational Materials (3)
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