产品号 #100-1622_C
Hamster (Armenian) monoclonal antibody against mouse CD80 (B7-1)
概述
This monoclonal antibody reacts with mouse cluster of differentiation 80 (CD80), a 55 kDa type I transmembrane protein ligand that is part of the immunoglobulin superfamily. CD80 is expressed by macrophages, dendritic cells, and activated B cells. CD80 is closely related to and works in tandem with CD86 (B7-2) to prime T cells. It has high affinity for binding to two T cell surface antigens, CD28 and CD152 (CTLA-4), and can deliver an inhibitory signal to T cells. Use this recombinant monoclonal antibody in applications requiring detection of CD80, such as flow cytometry (FC).
CD80 is significantly involved in immune cell activation in response to pathogens and acts as a cellular attachment receptor for adenovirus subgroup B. It is thought that CD80 interacts with a ligand on natural killer cells thus activating the natural killer cell-mediated cell death of the CD80 carrier. This phenomenon has potential as a possible cancer immunotherapy through the induction of CD80 expression on tumor cells. This antibody can be used as a marker to assess classically activated M1 murine macrophages.
Subtype
Primary Antibodies
Target Antigen
CD80 (B7-1)
Alternative Names
B7, B7-1, Cd28l, Ly-53, MIC17, TSA1
Reactive Species
Mouse
Conjugation
APC, FITC, PE
Host Species
Hamster
Cell Type
B Cells, Dendritic Cells, Macrophages, T Cells
Species
Mouse
Application
Flow Cytometry
Area of Interest
Immunology
Clone
16-10A1
Gene ID
12519
Isotype
Armenian hamster IgG
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Mouse CD80 (B7-1) Antibody, Clone 16-10A1, APC Catalog #
100-1624 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD80 (B7-1) Antibody, Clone 16-10A1, FITC Catalog #
100-1623 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD80 (B7-1) Antibody, Clone 16-10A1, PE Catalog #
100-1622 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD80 (B7-1) Antibody, Clone 16-10A1, APC Catalog #
100-1624 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD80 (B7-1) Antibody, Clone 16-10A1, FITC Catalog #
100-1623 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD80 (B7-1) Antibody, Clone 16-10A1, PE Catalog #
100-1622 Lot #
All Language
English Resources and Publications
Educational Materials (2)
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