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重组小鼠GM-CSF （CHO细胞表达）

粒细胞-巨噬细胞集落刺激因子
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产品号 #78206_C

粒细胞-巨噬细胞集落刺激因子

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总览

粒细胞-巨噬细胞集落刺激因子（GM-CSF）可促进造血祖细胞的增殖和分化以及中性粒细胞、嗜酸性粒细胞和巨噬细胞的产生。它与其他细胞因子如干细胞因子、IL-3、促红细胞生成素和促血小板生成素协同作用，能刺激红系和巨核系祖细胞的发育（Barreda 等人）。GM-CSF可由多种细胞类型产生，包括基质细胞、Paneth细胞、巨噬细胞、树突状细胞（DCs）、内皮细胞、平滑肌细胞、成纤维细胞、软骨细胞以及Th1和Th17细胞（Francisco-Cruz等人）。GM-CSF的受体（GM-CSFR）由两个亚基组成：细胞因子特异性α亚基(GMRα；CD116)和与IL-3和IL-5受体共享的共同亚基βc (CD131) （Broughton等人）。GM-CSFR在造血细胞上表达，包括祖细胞和免疫细胞，也在非造血细胞上表达。GM-CSF能够刺激DC的发育，这些细胞可摄取、加工并向免疫系统呈递抗原（Francisco-Cruz 等人）。

亚型
细胞因子
 
细胞类型
树突状细胞（DCs），造血干/祖细胞，单核细胞，髓系细胞
 
种属
小鼠
 
研究领域
免疫，干细胞生物学
 
纯度
≥ 95 %
 

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Data Figures

(A) The biological activity of Mouse Recombinant GM-CSF (CHO-expressed) was tested by its ability to promote the proliferation of FDCP1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 50 pg/mL. (B) 2 μg of Mouse Recombinant GM-CSF (CHO-expressed) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant GM-CSF (CHO-expressed) has a predicted molecular mass of 14.2 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Mouse Recombinant GM-CSF (CHO-expressed)
Catalog #
78206, 78206.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant GM-CSF (CHO-expressed)
Catalog #
78206, 78206.1
Lot #
All
Language
English

Resources and Publications

Educational Materials (5)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Reliable Antibodies for Your Research
Brochure
Reliable Antibodies for Your Research
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research
Human Hematopoietic Stem and Progenitor Cell Phenotyping
Wallchart
Human Hematopoietic Stem and Progenitor Cell Phenotyping
Human Immune Cytokines
Wallchart
Human Immune Cytokines

Publications (1)

Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection. J. M. Sweere et al. Science (New York, N.Y.) 2019

Abstract

Bacteriophage are abundant at sites of bacterial infection, but their effects on mammalian hosts are unclear. We have identified pathogenic roles for filamentous Pf bacteriophage produced by Pseudomonas aeruginosa (Pa) in suppression of immunity against bacterial infection. Pf promote Pa wound infection in mice and are associated with chronic human Pa wound infections. Murine and human leukocytes endocytose Pf, and internalization of this single-stranded DNA virus results in phage RNA production. This triggers Toll-like receptor 3 (TLR3)- and TIR domain-containing adapter-inducing interferon-beta (TRIF)-dependent type I interferon production, inhibition of tumor necrosis factor (TNF), and the suppression of phagocytosis. Conversely, immunization of mice against Pf prevents Pa wound infection. Thus, Pf triggers maladaptive innate viral pattern-recognition responses, which impair bacterial clearance. Vaccination against phage virions represents a potential strategy to prevent bacterial infection.
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Species Mouse
Purity ≥ 95%
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