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重组小鼠 Flt3/Flk-2配体

Fms样酪氨酸激酶3/胎肝激酶2
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产品号 #78011_C

Fms样酪氨酸激酶3/胎肝激酶2

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总览

Flt3/Flk-2（Fms样酪氨酸激酶3/胎肝激酶2）配体是一种造血细胞因子，作为共刺激因子，在造血干细胞和祖细胞的增殖、分化和存活以及免疫系统的发育中发挥着重要作用（Lyman et al.; Rosnet et al.）。Flt3/Flk-2 配体与干细胞因子和血小板生成素一起，常用于促进培养中原始造血细胞的扩增。Flt3/Flk-2 配体与髓系细胞因子，例如GM-CSF、G-CSF或M-CSF，结合使用，可增强克隆形成髓系祖细胞的生长和数量。 Flt3/Flk-2 配体与 IL-3、IL-4、IL-7、IL-11、IL-12、IL-15、GM-CSF 和 TNF-α 协同作用，调节各种淋巴祖细胞的发育，包括树突状细胞、B 细胞、T 细胞和 NK 细胞祖细胞。相反，Flt3/Flk-2 配体对红细胞生成或巨核细胞生成无显著影响  (Drexler & Quentmeier; Wodnar-Filipowicz)。

Flt3/Flk-2 配体以膜结合和可溶性亚型存在。两种亚型均具有生物活性，并通过 III 类酪氨酸激酶受体 (Flt3/Flk-2, CD135; Rosnet et al.) 发出信号。 Flt3/Flk-2 配体由多种细胞类型产生，包括未定向和定向的造血细胞及基质成纤维细胞，而 Flt3/Flk-2 受体的表达仅限于 CD34+ 造血干细胞和祖细胞。Flt3/Flk-2 受体也表达于白血病细胞以及脑、胎盘和睾丸等造血系统以外的细胞 (Drexler & Quentmeier; Hannum et al.)。

亚型
细胞因子
 
别名
FL；FLT3L；Flt3-L；Flt3 配体；类似 Fms 的酪氨酸激酶 3 配体
 
细胞类型
树突状细胞（DCs），造血干/祖细胞，NK 细胞
 
种属
小鼠
 
研究领域
免疫，干细胞生物学
 
纯度
≥ 95 %
 

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Data Figures

(A) The biological activity of Mouse Recombinant Flt3/Flk-2 Ligand was tested by its ability to promote the proliferation of AML5 cells. Cell proliferation was measured after 65 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 1.3 - 2.0 ng/mL.
(B) 1 μg of Mouse Recombinant Flt3/Flk-2 Ligand was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant Flt3/Flk-2 Ligand has a predicted molecular mass of 18.6 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Mouse Recombinant Flt3/Flk-2 Ligand
Catalog #
78011, 78011.1, 78011.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant Flt3/Flk-2 Ligand
Catalog #
78011, 78011.1, 78011.2
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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Resources and Publications

Educational Materials (2)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Human Immune Cytokines
Wallchart
Human Immune Cytokines

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更多信息
Species Mouse
Alternative Names FL, FLT3L, Flt3-L, Flt3 Ligand, Fms-like tyrosine kinase 3 ligand
Purity ≥ 95%
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