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抗小鼠CD48（SLAMF2）抗体，克隆HM48-1

仓鼠（亚美尼亚）抗小鼠 CD48（SLAMF2）单克隆 IgG1 抗体
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产品号 #60162_C

仓鼠（亚美尼亚）抗小鼠 CD48（SLAMF2）单克隆 IgG1 抗体

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总览

HM48-1抗体可与小鼠CD48发生反应。CD48是一种45 kDa GPI锚定糖蛋白，属于信号淋巴细胞活化分子(SLAM)家族和免疫球蛋白超家族。SLAM家族成员在免疫功能的多个方面发挥作用，包括共刺激、细胞毒性和细胞因子产生。CD48还在细胞粘附和T细胞活化中发挥作用。在小鼠中，CD48被认为存在于除中性粒细胞和ESLAM细胞（具有长期自我更新能力的CD45+EPCR+CD48-CD150+造血干细胞）以外的几乎所有造血细胞中。CD48的配体包括CD2和CD244，它们的结合有助于促进免疫细胞之间的相互作用。据报道，HM48-1能够在体外和体内阻断CD48:CD2和CD48:CD244的相互作用。此外，HM48-1 还能抑制脾细胞对有丝分裂原的增殖反应、抑制 CTL 活性并提高心脏移植的存活率。

亚型
一抗
 
靶抗原
CD48 (SLAMF2)
 
活性物种
小鼠
 
偶联
APC
 
宿主物种
Hamster
 
细胞类型
B 细胞，造血干/祖细胞，巨噬细胞，单核细胞，T 细胞
 
应用
流式细胞术
 
研究领域
免疫，干细胞生物学
 
克隆
HM48-1
 
基因编号
12506
 

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Data Figures

(A) Primary human airway epithelial cells were cultured in PneumaCult™-ALI Medium (Catalog #05001) at the air-liquid interface, then cryo-sectioned and labeled with Anti-Human MUC1 (CD227) Antibody, Clone 16A, followed by a goat anti-rabbit IgG antibody, Alexa Fluor® 594 (red), and an anti-human NGF Receptor/p75NTR (CD271) antibody, followed by a donkey anti-mouse IgG antibody, Alexa Fluor® 488 (green). (B) Flow cytometry analysis of human peripheral blood lymphocytes following stimulation with PHA for 3 days. Cells were labeled with Anti-Human MUC1 (CD227) Antibody, Clone 16A, followed by an anti-mouse IgG1 antibody, PE and anti-human CD3 antibody, Clone HIT3a, Pacific Blue™. (C) Flow cytometry analysis of human peripheral blood lymphocytes following stimulation with PHA for 3 days. Cells were labeled with Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21 (Catalog #60070), followed by an anti-mouse IgG1 antibody, PE, and anti-human CD3 antibody, clone HIT3a, Pacific Blue™.

(A) Flow cytometry analysis of human airway epithelial cells cultured in PneumaCult™-ALI Medium (Catalog #05001) at the air-liquid interface. Cells were enzymatically dissociated and labeled with Anti-Human MUC1 (CD227) Antibody, Clone 16A, PE (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE (Catalog #60070PE, solid line histogram). (C) Flow cytometry analysis human peripheral blood lymphocytes following stimulation with PHA for 3 days. Cells were labeled with Anti-Human MUC1 (CD227) Antibody, Clone 16A, PE and anti-human CD3 antibody, clone HIT3a, Pacific Blue™. (D) Flow cytometry analysis of PHA-activated human peripheral blood lymphocytes following stimulation with PHA for 3 days. Cells were labeled with Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE, and anti-human CD3 antibody, clone HIT3a, Pacific Blue™.

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD48 (SLAMF2) Antibody, Clone HM48-1, APC (filled histogram) or an Armenian hamster IgG isotype control antibody, APC (solid line histogram).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD48 (SLAMF2) Antibody, Clone HM48-1, APC
Catalog #
60162AZ, 60162AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD48 (SLAMF2) Antibody, Clone HM48-1, APC
Catalog #
60162AZ, 60162AZ.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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Workflow Stages

Resources and Publications

Educational Materials (2)

Reliable Antibodies for Your Research
Brochure
Reliable Antibodies for Your Research
Human Immune Cytokines
Wallchart
Human Immune Cytokines

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Clone HM48-1
Gene Id 12506
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