产品号 #78042_C
白介素3
概述
白细胞介素3 （IL-3）是一种物种特异性的多效性细胞因子，可促进多能造血干细胞和谱系特异性祖细胞的存活和增殖，并促进其分化为大多数谱系的成熟细胞，包括肥大细胞、嗜碱性细胞、中性粒细胞、嗜酸性细胞、巨噬细胞、树突状细胞、红细胞和巨核细胞(Fung等；Metcalf等人；Broughton等人)。IL-3由活化的T细胞产生，通过促进肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞分泌组胺、IL-4和IL-6等炎症介质，在炎症和过敏中具有生理作用。小鼠IL-3受体由一个独特的α亚基（CD123）和两个β亚基组成，一个特异于IL-3 (βIL-3)，另一个与IL-5和GM-CSF受体（β公共链，βc或CD131）共享。IL-3与含有α亚基和α亚基之一的异二聚体受体结合可激活JAK/STAT、MAPK和PI3K信号通路（Scott & Begley）。
Subtype
Cytokines
Cell Type
Hematopoietic Stem and Progenitor Cells, Mesoderm, PSC-Derived, Pluripotent Stem Cells
Species
Mouse
Area of Interest
Stem Cell Biology
Purity
≥ 95%
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (2)
更多信息
| Species | Mouse |
|---|---|
| Purity | ≥ 95% |
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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
