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重组人IL-4

白介素4
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产品号 #78045_C

白介素4

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总览

人白细胞介素 4 (IL-4) 对蠕虫感染的免疫应答以及过敏反应至关重要 (Olpihant et al.)。IL-4受体由IL-4Ra异二聚体和共同γ链组成。IL-4受体的结合导致JAK1/3的激活和STAT6和IRS1/2的募集 (Nelms et al.)。IL-4 驱动 B 细胞免疫球蛋白类别转换（转换为 IgE、IgG4）、肥大细胞增生、黏液产生以及幼稚 T 细胞分化为 Th2 细胞，后者产生 IL-4、IL-5、IL-10 和 IL-13 (Bao et al.; Nelms et al.; Olpihant et al.)。除 Th2 细胞外，CD4+ NK T 细胞、γ/δ T 细胞、活化嗜碱性粒细胞、嗜酸性粒细胞和肥大细胞也产生 IL-4。人 IL-4 不会与小鼠细胞发生交叉反应（Park et al.）。

亚型
细胞因子
 
细胞类型
B 细胞，树突状细胞（DCs），造血干/祖细胞，淋巴细胞，单核细胞，髓系细胞，神经元，T 细胞
 
种属
人
 
研究领域
免疫，神经科学，干细胞生物学
 
纯度
≥ 95 %
 

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Data Figures

(A) The biological activity of Human Recombinant IL-4 was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured after 72 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.16 - 0.24 ng/mL.
(B) 1 μg of Human Recombinant IL-4 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-4 has a predicted molecular mass of 15.1 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant IL-4
Catalog #
78045.3, 78045.2, 78045, 78045.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-4
Catalog #
78045.3, 78045.2, 78045, 78045.1
Lot #
All
Language
English

Resources and Publications

Educational Materials (3)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Tools for Your Immunology Research
Brochure
Tools for Your Immunology Research
Human Immune Cytokines
Wallchart
Human Immune Cytokines

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Species Human
Purity ≥ 95%
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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