产品号 #78025_C
白介素11
概述
白细胞介素11 （IL-11）是一种多效性细胞因子，作用于骨髓、脑和肠粘膜等多种组织（Du & Williams）。它属于IL-6细胞因子家族，它们共享一个共同的信号传感器gp130。IL-11诱导造血干细胞（Lemoli等人）和巨核细胞祖细胞（Bruno等人）的增殖、巨核细胞的成熟（Burstein等人）和血小板的产生（Neben等人）。IL-11由多种细胞类型产生，包括造血细胞、间充质细胞、上皮细胞和神经细胞。该基因首次从人骨髓源性基质细胞系KM-102 cDNA文库中克隆得到（Kawashima et al.）。IL-11与其受体的结合诱导gp130亚基的异源二聚化和JAK酪氨酸激酶的激活。IL-11是首个被批准用于治疗化疗引起的血小板减少症的药物。IL-11还通过诱导上皮癌细胞的增殖和远处器官转移细胞的存活，在癌症进展中发挥作用。最近，IL-11在与STAT3上调相关的粘膜稳态失调疾病的发病机制中所起的作用引起了人们的兴趣，包括胃肠道癌症（Putoczki等人）。
Subtype
Cytokines
Cell Type
B Cells, Hematopoietic Stem and Progenitor Cells, Other, Pluripotent Stem Cells, T Cells
Species
Human
Area of Interest
Cancer, Immunology, Stem Cell Biology
Purity
≥ 95%
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (3)
更多信息
| Species | Human |
|---|---|
| Purity | ≥ 95% |
相关产品
-
人重组IL-12白介素12
-
人重组IL-15白介素15
-
人重组IL-3（大肠杆菌表达）白介素3
-
人重组IL-4白介素4
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
