Interleukin 15 (IL-15) is a four-alpha helix bundle cytokine with many similar properties to IL-2, with which it shares components of its receptor. The IL-15 receptor is a heterotrimeric receptor composed of IL-15Ra, the high-affinity receptor for IL-15, as well as IL-2/15Rb (CD122) and common gamma chain (CD132). IL-15 binds to IL-15Rα receptor and can then be presented in trans to IL-2/15Rb and common gamma chain on other cells. Trans-presentation is thought to be the major mechanism by which IL-15-mediated responses occur in mice, although may not be necessary in humans (Castillo et al.). The cytoplasmic domains of IL-2/15Rb and common gamma chain mediate signaling to activate JAK/STAT and PI3K pathways. IL-15 supports the survival and proliferation of naive CD4+ and CD8+ T cells, and promotes homeostasis of memory T cells. IL-15 also promotes the survival and differentiation of NK cells and regulates their cytolytic activity (Ma et al.).
Data Figures
Figure 1. Biological Activity and Molecular Mass of Human Recombinant IL-15
(A) The biological activity of Human Recombinant IL-15 was tested by its ability to promote the proliferation of CTLL2 cells. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is ≤ 1 ng/mL.
(B) 1 g of Human Recombinant IL-15 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-15 has a predicted molecular mass of 12.9 kDa.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet 1
Product Name
Human Recombinant IL-15
Catalog #
78031.1, 78031.3, 78031
Lot #
For 78031: Lot 1000121459 or higher | For 78031.1: Lot 1000107799 or higher | For 78031.2: Lot 1000110466 or higher | For 78031.3: All
Language
English
Document Type
Product Information Sheet 2
Product Name
Human Recombinant IL-15
Catalog #
78031.1, 78031
Lot #
For 78031: Lot 1000121458 or lower | For 78031.1: Lot 1000107798 or lower | For 78031.2: 1000110465 or lower
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-15
Catalog #
78031.1, 78031.3, 78031
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Workflow Stages for Hematopoietic Stem and Progenitor Cell Research
Workflow Stages for Total Lymphocyte Research
Workflow Stages for Natural Killer Cell Research
Workflow Stages for T Cell Research
Resources and Publications
Educational Materials (3)
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