产品号 #78035_C
白细胞介素1
概述
白细胞介素1β (IL-1β)作为无活性前体蛋白或IL-1β前体合成。这种前体被半胱天蛋白酶1 （IL-1β转化酶）在细胞内切割，形成活性形式的蛋白质，随后被分泌（Allan等）。IL-1β与IL-1受体结合，通过MAPK或NF-kB途径激活细胞内信号传导。IL-1β由单核细胞、组织巨噬细胞和树突状细胞在感染或损伤时释放，并诱导急性期蛋白的表达。它还通过刺激内皮细胞上粘附分子的表达，促进炎症和免疫能力细胞从循环向血管外空间和受累组织浸润。IL-1β也影响其他免疫细胞；例如，它与抗原或有丝分裂原共同刺激T细胞功能。它还以依赖il -6的方式刺激Th17分化和B细胞增殖。IL-1β缺失小鼠与野生型小鼠无表型差异；然而，它们对炎症的反应降低，这表明IL-1β在炎症性疾病中起关键作用（Dinarello）。
Subtype
Cytokines
Cell Type
Hematopoietic Stem and Progenitor Cells
Species
Mouse
Area of Interest
Immunology, Stem Cell Biology
Purity
≥ 95%
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (3)
更多信息
| Species | Mouse |
|---|---|
| Purity | ≥ 95% |
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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
