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重组人VEGF-165

血管内皮生长因子
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产品号 #78073_C

血管内皮生长因子

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总览

血管内皮生长因子 (VEGF-165) 是一种参与胚胎血管生成和血管生成 (angiography, angiogeneration) 的肝素结合同型二聚体糖蛋白。VEGF 与 VEGFR-1 (R1) 和 VEGFR-2 (R2) 结合，并激活 Raf/MEK/ERK 和 PI3K/AKT 通路 (Ferrara et al.)。它在体内和体外神经发生中均发挥重要作用 (Storkebaum et al.)。它对中枢神经系统的神经元具有神经营养作用，并促进多巴胺能神经元和星形胶质细胞的生长和存活。VEGF 还促进血管内皮细胞的生长和存活、单核细胞趋化以及粒细胞-巨噬细胞祖细胞的集落形成 (Ferrara et al.)。

亚型
细胞因子，生长因子
 
细胞类型
血管生成细胞，内皮细胞，造血干/祖细胞，间充质干/祖细胞，中胚层，PSC衍生，神经干/祖细胞，多能干细胞
 
种属
人
 
研究领域
血管生成细胞研究，内皮细胞研究，神经科学，干细胞生物学
 
纯度
≥ 95 %
 

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Data Figures

(A) The biological activity of Human Recombinant VEGF-165 was tested by its ability to promote the proliferation of HUVECs. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 1.7 ng/mL. (B) 4 μg of Human Recombinant VEGF-165 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant VEGF-165 has a predicted molecular mass of 38.2 kDa by non-reducing SDS-PAGE.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant VEGF-165
Catalog #
78073, 78073.2, 78073.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant VEGF-165
Catalog #
78073, 78073.2, 78073.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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Species Human
Purity ≥ 95%
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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