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重组人BMP-2

骨形态发生蛋白2
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产品号 #（选择产品）

产品号 #78004_C

骨形态发生蛋白2

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总览
实验数据
产品说明书及文档
应用领域
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总览

骨形态发生蛋白2 （BMP-2）是转化生长因子β (TGF-β)超家族的一员。BMP-2是一种二硫连接的同二聚体，作为I型和II型BMP受体复合物的配体，主要激活SMAD1/5/8信号传导（Nohe等人）。BMP-2是一种有效的分化因子，可引导人多能干细胞（hPSCs）分化为各种细胞类型，包括胚胎外内胚层、间充质细胞和软骨细胞（Pera等人）。尽管BMP-2在健康软骨中的表达较低，但其在软骨损伤部位的表达上调（Blaney Davidson等人）。BMP-2在体外诱导骨和软骨形成，并能诱导人间充质干细胞成软骨（Schmitt等人）。

亚型
细胞因子
 
细胞类型
内胚层，PSC衍生，造血干/祖细胞，中胚层，PSC衍生，多能干细胞
 
种属
人
 
研究领域
上皮细胞研究，神经科学，干细胞生物学
 
纯度
≥ 95 %
 

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Data Figures

(A) The biological activity of Human Recombinant BMP-2 was tested by its ability to promote alkaline phosphatase production of ATDC-5 cells. Alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which alkaline phosphatase production is at 50% of maximum. The EC50 in the above example is 0.09 μg/mL.
(B) 2 μg of Human Recombinant BMP-2 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant BMP-2 has a predicted molecular mass of 26 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant BMP-2
Catalog #
78004, 78004.1, 78004.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant BMP-2
Catalog #
78004, 78004.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (1)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors

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Species Human
Purity ≥ 95%
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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