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人重组SCF（P. pastoris表达）

干细胞因子
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产品号 #100-1712_C

干细胞因子

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总览

干细胞因子 (SCF) 是一种早期作用的细胞因子，在胚胎和成人造血的调控中起着关键作用。SCF 促进细胞存活、增殖、分化、粘附以及在造血系统多个层面的功能性激活。SCF 与其他细胞因子，例如血小板生成素和 Flt3/Flk-2 配体一起，常用于促进培养的原始造血干细胞和多能祖细胞的扩增 (Martin et al.; Kent et al.)。SCF 与多种生长因子，包括 IL-2、IL-3、IL-6、IL-7、G-CSF 和促红细胞生成素协同作用，促进髓系和红系祖细胞以及部分淋巴系祖细胞的增殖和分化 (Broudy)。SCF 也是肥大细胞和嗜酸性粒细胞的主要生长和活化因子。

SCF 有两种生物活性剪接变体：可溶性和跨膜型。与其受体（c-Kit 酪氨酸激酶受体；CD117）结合后，SCF 可激活 PI3K、JAK/STAT 和 MAPK 通路。据报道，SCF及其介导的c-Kit信号在多个生理过程中发挥重要作用，包括色素生成、生育力、血管生成、Cajal间质细胞介导的胃肠道运动调节，以及神经干/祖细胞向脑损伤区域迁移等过程。

亚型
细胞因子
 
别名
Kit配体，肥大细胞生长因子，Steel因子，干细胞因子
 
细胞类型
造血干/祖细胞，中胚层，PSC衍生，多能干细胞
 
种属
人
 
研究领域
干细胞生物学
 
纯度
≥ 95 %
 

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Data Figures

Figure 1. Biological Activity and Molecular Mass of Human Recombinant SCF (P. pastoris-expressed)

(A) The biological activity of Human Recombinant SCF (P. pastoris-expressed) was tested by its ability to promote the stimulation of human TF-1 cells. The EC50 is defined as the effective concentration of the growth factor at which stimulation is at 50% of maximum. The EC50 in the above example is ≤ 2 ng/mL. (B) 2 μg Human Recombinant SCF (P. pastoris-expressed) was resolved with SDS-PAGE under non-reducing (-) and reducing (+) conditions. Human Recombinant SCF has a predicted molecular mass of 18.6 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant SCF (P. pastoris-expressed)
Catalog #
100-1712, 100-1713
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant SCF (P. pastoris-expressed)
Catalog #
100-1712
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant SCF (P. pastoris-expressed)
Catalog #
100-1713
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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Species Human
Alternative Names Kit ligand, Mast cell growth factor, Steel factor, Stem cell factor
Purity ≥ 95%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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