人重组半乳糖凝集素-1

半乳糖凝集素-1

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产品号 #100-0941_C

半乳糖凝集素-1

半乳糖凝集素-1 (Gal1)是首个被鉴定的半乳糖苷酶结合蛋白半乳糖凝集素家族中的成员,目前已鉴定出 15 种以上的哺乳动物半乳糖凝集素(Camby等;Salatino等)。Gal1具有两种形式:作为细胞因子的氧化单体和可作为凝集素的还原二聚体(Gaudet等)。这个产品是二聚体形式。该细胞因子在多种组织中表达,并在T 细胞稳态调节中发挥免疫抑制作用,其机制包括调控细胞凋亡、细胞因子分泌、细胞黏附、细胞增殖等 (Camby等;Garín等;Gaudet等人;Salatino等)。此外,Gal1也被认为在神经损伤后的轴突再生中发挥作用(Camby等;Garín等;Gaudet等;Salatino等)。Gal1有多种治疗应用;过度表达Gal1 已被认为是一种治疗自身免疫性和炎症性疾病的方法,并可促进受损神经的轴突再生(Camby等;Gaudet等)。相反,抑制 Gal1 表达 被认为可能有助于阻止肿瘤转移和癌症进展,因为它可能促进肿瘤细胞的黏附、迁移和免疫逃逸(Camby 等)。

Data Figures

Figure 1.

Human Recombinant Galectin-1 was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining. Human Recombinant Galectin-1 monomer has a predicted molecular mass of 15 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-0941
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-0941
Lot #
All
Language
English

Resources and Publications

Educational Materials (2)

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更多信息
Species Human
Alternative Names 14 kDa laminin-binding protein, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, GAL1, Galactose-specific lectin-1, Galaptin, LGALS1, S-LAC lectin-1
Purity ≥ 95%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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