产品号 #78171_C
表皮生长因子受体
表皮生长因子受体(EGFR)是一种 I 型跨膜蛋白和酪氨酸激酶受体。EGFR已被证实可与表皮生长因子(EGF)家族的某些配体结合,包括EGF、amphiregulin、TGF-α、betacellulin、epiregulin、肝素结合型EGF以及neuregulin-2α。EGFR配体结合会诱导EGFR的同源二聚化,以及EGFR与ErbB2或与配体激活的ErbB3或ErbB4的异源二聚化(Schlessinger)。二聚化可导致激酶激活、磷酸化和细胞信号传导,主要通过MEK/ERF和AKT通路介导(Navlonic等)。EGFR信号传导已被证实可调节细胞增殖、分化、迁移及凋亡。EGFR水平升高与致癌作用相关(Maihle等)。蛋白质在多肽链的羧基端含有一个 His 残基标签。
亚型
细胞因子,生长因子
别名
鸟类红细胞白血病病毒癌基因同源物,表皮生长因子受体,Erb-b2受体酪氨酸激酶1,ERBB1,原癌基因c-ErbB-1,受体酪氨酸蛋白激酶erbB-1,v-erb-b
细胞类型
脑肿瘤干细胞,内胚层,PSC衍生,造血干/祖细胞,间充质干/祖细胞,中胚层,PSC衍生,神经细胞,PSC衍生,神经干/祖细胞,神经元,多能干细胞,前列腺细胞
种属
人
研究领域
上皮细胞研究,神经科学,干细胞生物学
分子量
69.4 千道尔顿
纯度
≥ 95 %
(A) The biological activity of Human Recombinant EGFR was tested by its ability to promote the proliferation of BALB/c 3T3 cells in the presence of 25 pg/mL EGF. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.81 µg/mL. (B) 2 μg of Human Recombinant EGFR was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant EGFR has a predicted molecular mass of 69.4 kDa.
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Molecular Weight | 69.4 kDa |
---|---|
Species | Human |
Alternative Names | Avian erythroblastic leukemia viral oncogene homolog, Epidermal growth factor receptor, Erb-b2 receptor tyrosine kinase 1, ERBB1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, v-erb-b |
Purity | ≥ 95% |
哺乳动物活细胞计数试剂
碱性成纤维细胞生长因子
表皮生长因子
血管内皮生长因子
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