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人重组BDNF，ACF

脑源性神经营养因子，不含动物成分
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产品号 #78133_C

脑源性神经营养因子，不含动物成分

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脑源性神经营养因子（BDNF）与神经生长因子（NGF）、神经营养因子-3 （NT-3）和神经营养因子-4 （NT-4）一样，属于神经营养因子NGF家族，是中枢和周围神经系统中特定神经元亚群分化和存活所必需的（Minichiello & Klein; Minichiello et al.）。BDNF以高亲和力结合TRKB激酶受体，激活AKT和ERK通路（Mattson et al.）。它在基底前脑的海马体、皮质和突触中表达。当BDNF接种于饲养层细胞或Corning® Matrigel®基质胶上时，可作为人胚胎干细胞的存活因子（Pyle et al.）。BDNF调节中枢神经系统成熟突触的突触传递和可塑性，参与包括长期增强、长期抑制、某些形式的短期突触可塑性的适应性神经元反应，以及神经元兴奋性的稳态调节（Reichardt）。它还通过促进背根神经节细胞、海马体和皮质神经元的存活和生长而在神经发生中发挥作用（Binder & Scharfman）。BDNF与神经胶质细胞来源的神经营养因子（GDNF）和其他添加物一起，通常用于将人多能干细胞（hPSC）来源的神经祖细胞分化为神经元（Brafman）。本产品不含动物成分。
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Data Figures

(A) The biological activity of Human Recombinant BDNF, ACF was tested by its ability to promote the proliferation of a neuroblastoma cell line stably expressing TrkB (BR6). Cell proliferation was measured using a colorimetric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 5 ng/mL. For a representative bioactivity plot of C6 cell proliferation, contact us at techsupport@stemcell.com.
(B) 1 μg of Human Recombinant BDNF, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant BDNF, ACF is a homodimer of 13.6 kDa subunits with a predicted molecular mass of 27.3 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Human Recombinant BDNF, ACF
Catalog #
78133.1, 78133, 78133.2
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant BDNF, ACF
Catalog #
78133.1, 78133, 78133.2
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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Species Human
Formulation Category Animal Component-Free
Purity ≥ 95%
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
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