产品号 #100-1633_C
Rat monoclonal antibody against mouse CD8a
概述
This monoclonal antibody (clone CD8a) reacts with mouse cluster of differentiation 8 subunit alpha (CD8a), a 32 - 34 kDa type I transmembrane glycoprotein. CD8 is a disulfide-bonded dimer, found either as a heterodimer of CD8a (α) and CD8b (β) subunits (i.e. αβ) or a homodimer (αα). Use this recombinant monoclonal antibody in applications requiring detection of CD8a, such as flow cytometry (FC).
CD8 is expressed in the αβ form by a majority of thymocytes and a subset of mature peripheral blood T cells (T cytotoxic cells), and in the ββ form by γδ T cells, a subset of intestinal intraepithelial lymphocytes, and dendritic cells. CD8 acts as a co-receptor to the T cell receptor (TCR) during T cell activation by binding to the major histocompatibility (MHC) Class I molecules presented by an antigen-presenting cell. The CD8a chain binds to the alpha3 domain of MHC class I molecules. It functions to strengthen the association between the TCR and MHC I-antigen complex and to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases, such as lymphocyte-specific protein tyrosine kinase (Lck). This antibody is used as a phenotypic marker for mouse CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not express the TCR, which includes some natural killer cells and lymphoid dendritic cells.
Subtype
Primary Antibodies
Target Antigen
CD8a
Alternative Names
CD8 alpha, Ly-2, Ly-35, Ly-B, Lyt-2
Reactive Species
Mouse
Conjugation
APC, FITC, Unconjugated
Host Species
Rat
Cell Type
T Cells, CD8+
Species
Mouse
Application
Flow Cytometry
Area of Interest
Immunology
Clone
2.43
Gene ID
12525
Isotype
IgG2b, kappa
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Mouse CD8a Antibody, Clone 2.43, APC Catalog #
100-1634 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD8a Antibody, Clone 2.43, FITC Catalog #
100-1635 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD8a Antibody, Clone 2.43 Catalog #
100-1633 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD8a Antibody, Clone 2.43, APC Catalog #
100-1634 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD8a Antibody, Clone 2.43, FITC Catalog #
100-1635 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD8a Antibody, Clone 2.43 Catalog #
100-1633 Lot #
All Language
English Resources and Publications
Educational Materials (2)
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