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抗小鼠CD49b抗体，克隆DX5

大鼠单克隆IgM抗体，抗小鼠CD49b（整合素α2）
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产品号 #60020_C

大鼠单克隆IgM抗体，抗小鼠CD49b（整合素α2）

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总览
实验数据
产品说明书及文档
应用领域
相关材料与文献
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总览

DX5抗体识别小鼠CD49b（整合素α2），CD49b是一种~150 kDa的1型跨膜糖蛋白，与CD29（整合素β1）非共价结合，形成异二聚体CD49b/CD29复合物，又称为VLA-2，是细胞外基质蛋白如胶原蛋白、e -钙粘蛋白、纤维连接蛋白和层粘连蛋白的受体。CD49b在血小板中高表达，也存在于大多数NK细胞、NKT细胞和一小部分CD8+ T细胞中；CD49b+CD8+ T细胞在病毒感染后大幅增加。CD49b也在肠、肾、乳腺和肺等组织中表达。DX5抗体特别有助于鉴定缺乏NK1.1抗原的小鼠的NK细胞。DX5抗体的结合还未被观察到会影响VLA-2整合素的功能。不过，DX5的结合会被抗体克隆HMα2阻断。

该抗体克隆已被验证可用于评估EasySep™小鼠NK细胞富集试剂盒（产品号 #19755）分选的细胞纯度。

亚型
一抗
 
靶抗原
CD49b (Integrin α2)
 
别名
α2整合素，整合素α2链，VLA-2α链
 
活性物种
小鼠
 
偶联
Alexa Fluor 488，APC，Biotin 或 生物素，FITC，Pacific Blue，PE，未偶联的
 
宿主物种
大鼠
 
细胞类型
NK 细胞
 
种属
小鼠
 
应用
细胞分选，流式细胞术，免疫组化
 
研究领域
免疫
 
克隆
DX5
 
基因编号
16398
 
同种型
IgM，kappa
 

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Data Figures

Data for Alexa Fluor® 488-Conjugated

Figure 1. Data for Alexa Fluor® 488-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD49b Antibody, Clone DX5, Alexa Fluor® 488 and Anti-Mouse CD45 Antibody, Clone 30-F11, APC (Catalog #60030AZ). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Rat IgM, kappa Isotype Control Antibody, Clone RTK2118, Alexa Fluor® 488 (Catalog #60074AD) and Anti-Mouse CD45 Antibody, Clone 30-F11, APC.

Data for PE-Conjugated

Figure 2. Data for PE-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD49b Antibody, Clone DX5, PE and Anti-Mouse CD45 Antibody, Clone 30-F11, APC (Catalog #60030AZ). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Rat IgM, kappa Isotype Control Antibody, Clone RTK2118, PE (Catalog #60074PE) and Anti-Mouse CD45 Antibody, Clone 30-F11, APC.

Data for Unconjugated

Figure 3. Data for Unconjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD49b Antibody, Clone DX5, followed by a mouse anti-rat IgM antibody, FITC and Anti-Mouse CD45 Antibody, Clone 30-F11, PE (Catalog #60030PE). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Rat IgM, kappa Isotype Control Antibody, Clone RTK2118 (Catalog #60074), followed by a mouse anti-rat IgM antibody, FITC and Anti-Mouse CD45 antibody, Clone 30-F11, PE.

Data for APC-Conjugated

Figure 4. Data for APC-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD49b Antibody, Clone DX5, APC and Anti-Mouse CD45 Antibody, Clone 30-F11, FITC (Catalog #60030FI). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Rat IgM, kappa Isotype Control Antibody, Clone RTK2118, APC (Catalog #60074AZ) and Anti-Mouse CD45 Antibody, Clone 30-F11, FITC.

Data for Biotin-Conjugated

Figure 5. Data for Biotin-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD49b Antibody, Clone DX5, Biotin, followed by streptavidin (SAV) APC and Anti-Mouse CD45 Antibody, Clone 30-F11, FITC (Catalog #60030FI). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Rat IgM, kappa Isotype Control Antibody, Clone RTK2118, Biotin (Catalog #60074BT), followed by SAV APC and Anti-Mouse CD45 Antibody, Clone 30-F11, FITC.

Data for FITC-Conjugated

Figure 6. Data for FITC-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD49b Antibody, Clone DX5, FITC and Anti-Mouse CD45 Antibody, Clone 30-F11, PE (Catalog #60030PE). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Rat IgM, kappa Isotype Control Antibody, Clone RTK2118, FITC (Catalog #60074FI) and Anti-Mouse CD45 Antibody, Clone 30-F11, PE.

Figure 7. Data for PB-Conjugated

(A) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD49b Antibody, Clone DX5, Pacific Blue™ and Anti-Mouse CD45 Antibody, Clone 30-F11, FITC (Catalog #60030FI). (B) Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with a rat IgM, kappa Pacific Blue™ isotype control antibody and Anti-Mouse CD45 Antibody, Clone 30-F11, FITC.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD49b Antibody, Clone DX5, APC
Catalog #
60020AZ, 60020AZ.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD49b Antibody, Clone DX5, Biotin
Catalog #
60020BT
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD49b Antibody, Clone DX5, PE
Catalog #
60020PE, 60020PE.1
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Mouse CD49b Antibody, Clone DX5
Catalog #
60020
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD49b Antibody, Clone DX5, APC
Catalog #
60020AZ, 60020AZ.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD49b Antibody, Clone DX5, Biotin
Catalog #
60020BT
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD49b Antibody, Clone DX5, PE
Catalog #
60020PE, 60020PE.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Mouse CD49b Antibody, Clone DX5
Catalog #
60020
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (3)

Reliable Antibodies for Your Research
Brochure
Reliable Antibodies for Your Research
Tools for Your Immunology Research
Brochure
Tools for Your Immunology Research
Human Immune Cytokines
Wallchart
Human Immune Cytokines

更多信息

更多信息
Species Mouse
Clone DX5
Gene Id 16398
Alternative Names α2 integrin, Integrin α2 chain, VLA-2α chain
Isotype IgM, kappa
Legal Statement: Alexa Fluor and Pacific Blue are trademarks of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® or Pacific Blue™ are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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