产品号 #100-1606_C
Rat monoclonal antibody against mouse CD3
概述
This monoclonal antibody (clone 17A2) reacts with the mouse cluster of differentiation 3 (CD3) complex, which consists of epsilon, gamma, delta, and zeta polypeptide chains. CD3 is a member of the immunoglobulin superfamily and is primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3 protein chains assemble with chains of T cell receptor (TCR) and together they form the TCR-CD3 complex. Use this recombinant monoclonal antibody in applications requiring detection of CD3, such as flow cytometry (FC) and the unconjugated antibody in Immunoprecipitation (IP) and FC.
TCR-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. This complex is critical for T cell development and function, and it represents one of the most complex transmembrane receptors. Blocking studies using a CD3E-targeting antibody suggests that the 17A2 clone of CD3 antibody recognizes an epitope on the epsilon chain of the CD3 complex. The 17A2 antibody clone is widely used as a phenotypic marker for mouse T cells. In addition, as the CD3E chain within the TCR-CD3 complex contains intracellular signaling domains, binding of the 17A2 antibody clone to CD3 can induce cell activation.
Subtype
Primary Antibodies
Target Antigen
CD3
Alternative Names
CD3 epsilon, T3 complex, T cell antigen receptor complex
Reactive Species
Mouse
Conjugation
APC, FITC, PerCP-Cyanine5.5, Unconjugated
Host Species
Rat
Cell Type
T Cells
Species
Mouse
Application
Flow Cytometry
Area of Interest
Immunology
Clone
17A2
Gene ID
12501
Isotype
IgG2b, kappa
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Mouse CD3 Antibody, Clone 17A2, APC Catalog #
100-1607 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD3 Antibody, Clone 17A2, FITC Catalog #
100-1609 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD3 Antibody, Clone 17A2, PerCP-Cy5.5 Catalog #
100-1608 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Mouse CD3 Antibody, Clone 17A2 Catalog #
100-1606 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD3 Antibody, Clone 17A2, APC Catalog #
100-1607 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD3 Antibody, Clone 17A2, FITC Catalog #
100-1609 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD3 Antibody, Clone 17A2, PerCP-Cy5.5 Catalog #
100-1608 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Mouse CD3 Antibody, Clone 17A2 Catalog #
100-1606 Lot #
All Language
English Resources and Publications
Educational Materials (2)
Request Pricing
Thank you for your interest in IntestiCult™ Organoid Growth Medium (Human). Please provide us with your contact information and your local representative will contact you with a customized quote. Where appropriate, they can also assist you with a(n):
Estimated delivery time for your area
Product sample or exclusive offer
In-lab demonstration
By submitting this form, you are providing your consent to STEMCELL Technologies Canada Inc. and its subsidiaries and affiliates (“STEMCELL”) to collect and use your information, and send you newsletters and emails in accordance with our
privacy policy. Please contact us with any questions that you may have. You can unsubscribe or change your email preferences at any time.
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.
欢迎您关注STEMCELL Technologies的微信公众平台
扫描二维码或搜索微信号STEMCELLTech，即可关注我们的微信平台，第一时间接收丰富的技术资源和最新的活动信息。
如您有任何问题，欢迎发消息给STEMCELLTech微信公众平台，或与我们通过电话/邮件联系：400 885 9050 INFO.CN@STEMCELL.COM。