产品号 #60091_C
小鼠抗人食蟹蟹巢蛋白单克隆IgG1抗体
概述
10C2抗体与人巢蛋白反应，巢蛋白是一种由发育中的神经系统中的胚胎神经上皮干细胞、胰岛细胞和间充质祖细胞表达的VI类中间丝蛋白。在胶质母细胞瘤和许多原发性和转移性黑色素瘤中也观察到Nestin的表达，它是评估肿瘤内皮细胞新生血管的有用血管生成标志物。Nestin是神经祖细胞存活和更新所必需的，并通过与vimentin或α -间连蛋白形成异源二聚体在细胞重塑中发挥作用，这一过程似乎受到磷酸化的严格调节。巢蛋白在分化神经元轴突伸长过程中定位于生长锥，可能在生长锥引导中起作用。Nestin的表达在分化过程中下调，通常在胚胎期E18消失。据报道，10C2抗体与猴巢蛋白有弱交叉反应，而与啮齿动物巢蛋白无交叉反应。在western blots上观察到~220 - 250kda的双峰带。
Subtype
Primary Antibodies
Target Antigen
Nestin
Alternative Names
NES, type VI intermediate filament (IF) protein
Reactive Species
Cynomolgus, Human
Conjugation
Alexa Fluor 488, Unconjugated
Host Species
Mouse
Cell Type
Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons
Species
Human, Non-Human Primate
Application
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Area of Interest
Neuroscience, Stem Cell Biology
Clone
10C2
Gene ID
10763
Isotype
IgG1, kappa
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (2)
更多信息
| Species | Human, Non-Human Primate |
|---|---|
| Clone | 10C2 |
| Gene Id | 10763 |
| Alternative Names | NES, type VI intermediate filament (IF) protein |
| Isotype | IgG1, kappa |
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Legal Statement: Alexa Fluor is a registered trademark of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
