切换导航
  • 比较产品
我的购物车

抗人HLA-DR，克隆L243

抗人、恒河猴、食蟹猴HLA-DR的小鼠单克隆IgG2a抗体
率先评论此产品
添加并比较

产品号 #（选择产品）

产品号 #100-0308_C

抗人、恒河猴、食蟹猴HLA-DR的小鼠单克隆IgG2a抗体

main product photo
总览
实验数据
产品说明书及文档
应用领域
相关产品

总览

L243抗体可特异性识别人HLA-DR，HLA-DR是主要组织相容性复合物（MHC） II类受体，属于免疫球蛋白超级家族。HLA-DR是一种异源二聚体跨膜糖蛋白，由一个36 kDa的α亚基与一个27 kDa的β亚基以非共价结合而成，表达于抗原递呈细胞（如B细胞、活化T细胞、单核细胞、巨噬细胞和树突状细胞）、活化NK细胞和祖细胞的表面。HLA-DR与CD3/T细胞受体（TCR）复合物和CD4分子协同作用，介导抗原递呈细胞将外源抗原水解产生的肽递呈给CD4+ T（辅助）细胞，从而调控针对这些肽的免疫激活或抑制反应。因此，HLA-DR与移植物抗宿主病和几种自身免疫性疾病相关。L243抗体可结合α链上的一个胞外、构象性和非多态性表位，该表位仅在正确折叠的αβ异源二聚体表达，并且结合不依赖于HLA-DR与抗原肽装载。该抗体的结合阻断HLA-DR与TCR的结合，研究发现其对人细胞具有细胞毒性作用。L243抗体不与HLA-DQ或HLA-DP发生交叉反应。

亚型
一抗
 
靶抗原
HLA-DR
 
别名
HLA-DRA，主要组织相容性复合体 II类，主要组织相容性复合体 II类 DR α链，MHC II，MHC II类 DR α链，MGC117330，MLRW
 
活性物种
African Green Monkey，Baboon，Chimpanzee，Common Marmoset，Cotton-Topped Tamarin，Cynomolgus，Dog，人，Pigtailed Macaque，Rhesus，Squirrel Monkey
 
偶联
APC，APC-Cyanine7，FITC，PE
 
宿主物种
小鼠
 
细胞类型
B 细胞，巨噬细胞，单核细胞，T 细胞
 
应用
流式细胞术，免疫组化
 
研究领域
免疫
 
克隆
L243
 
基因编号
3122，3123
 
同种型
IgG2a，kappa
 

查看更多 显示更少

Data Figures

Figure showing flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human HLA-DR Antibody, Clone L243, APC or a mouse IgG2a, kappa APC isotype control antibody.

Figure 1. Data for Anti-Human HLA-DR Antibody, Clone L243, APC

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human HLA-DR Antibody, Clone L243, APC (filled histogram) or a mouse IgG2a, kappa APC isotype control antibody (solid line histogram). Viable lymphocytes were gated for analysis.

Figure showing flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human HLA-DR Antibody, Clone L243, APC-Cyanine7 or a mouse IgG2a, kappa APC-Cyanine7 isotype control antibody.

Figure 2. Data for Anti-Human HLA-DR Antibody, Clone L243, APC-Cy7

Flow cytometry analysis of human PBMCs labeled with Anti-Human HLA-DR Antibody, Clone L243, APC-Cyanine7 (filled histogram) or a mouse IgG2a, kappa APC-Cyanine7 isotype control antibody (solid line histogram). Viable lymphocytes were gated for analysis.

Figure showing flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human HLA-DR Antibody, Clone L243, FITC or a mouse IgG2a, kappa FITC isotype control antibody.

Figure 3. Data for Anti-Human HLA-DR Antibody, Clone L243, FITC

Flow cytometry analysis of human PBMCs labeled with Anti-Human HLA-DR Antibody, Clone L243, FITC (filled histogram) or a mouse IgG2a, kappa FITC isotype control antibody (solid line histogram). Viable lymphocytes were gated for analysis.

Figure showing flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human HLA-DR Antibody, Clone L243, PE or a mouse IgG2a, kappa PE isotype control antibody.

Figure 4. Data for Anti-Human HLA-DR Antibody, Clone L243, PE

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human HLA-DR Antibody, Clone L243, PE (filled histogram) or a mouse IgG2a, kappa PE isotype control antibody (solid line histogram). Viable lymphocytes were gated for analysis.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-Human HLA-DR, Clone L243, PE
Catalog #
100-0312
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human HLA-DR, Clone L243, PE
Catalog #
100-0312
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

更多信息

更多信息
Clone L243
Gene Id 3122, 3123
Alternative Names HLA-DRA, Major histocompatibility class II, Major histocompatibility class II DR alpha, MHC class II, MHC class II DR alpha, MGC117330, MLRW
Isotype IgG2a, kappa
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
版权 © 2025 STEMCELL Technologies 技术有限公司。保留所有权利。