产品号 #60164_C
抗人、恒河猴HLA-DR的小鼠单克隆IgG2b抗体
总览
LN3抗体可特异性识别 HLA-DR抗原，HLA-DR抗原是6号染色体上人白细胞抗原（HLA）复合物内编码的主要组织相容性复合体（MHC） II类受体。HLA-DR是一种异二聚跨膜糖蛋白，由非共价结合的α (36 kDa)和β (27 kDa) 亚基组成。MHC II类受体在将抗原来源肽递呈给CD4+ T细胞以及CD3/TCR和CD4的过程中起着关键作用。HLA-DR主要表达于抗原递呈细胞的表面，包括B细胞、树突状细胞、单核细胞、巨噬细胞、胸腺上皮细胞以及活化的T细胞和自然杀伤（NK）细胞。据报道，LN3抗体特异性结合HLA-DR的HLA-BR1亚基胞外区。
亚型
一抗
靶抗原
HLA-DR
别名
HLA II类组织相容性抗原，HLA-DR α链，HLA-DRA，HLA DRA1，HLA DR1B，HLA DR3B，HLA DRB1，HLA DRB3，HLA DRB4，HLA DRB5，HLA DR4B，HLA DRA1，HLA DRB，主要组织相容性复合体 II类，MHC II，MHC II类抗原 DRA，MLRW
活性物种
人，Rhesus
偶联
Alexa Fluor 488，FITC，PE，未偶联的
宿主物种
小鼠
细胞类型
B 细胞，树突状细胞（DCs），巨噬细胞，单核细胞，其它细胞系，T 细胞
应用
流式细胞术，功能学筛选，免疫组化
研究领域
HLA，免疫，感染性疾病(传染病)，移植研究
克隆
LN3
基因编号
3123
同种型
IgG2b，kappa
Data Figures
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (2)
更多信息
| Clone | LN3 |
|---|---|
| Gene Id | 3123 |
| Alternative Names | HLA class II histocompatibility antigen, HLA-DR alpha, HLA-DRA, HLA DRA1, HLA DR1B, HLA DR3B, HLA DRB1, HLA DRB3, HLA DRB4, HLA DRB5, HLADR4B, HLADRA1, HLADRB, Major histocompatibility class II, MHC II, MHC class II, MHC class II antigen DRA, MLRW |
| Isotype | IgG2b, kappa |
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Legal Statement: Alexa Fluor is a registered trademark of Life Technologies Corporation. Antibodies conjugated to Alexa Fluor® are licensed for internal research use only and sale is expressly conditioned on the buyer not using the antibody for manufacturing, performing a service or medical test, or otherwise generating revenue. For use other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
