抗人CD80 (B7-1)抗体,克隆2D10.4

小鼠抗人恒河猴CD80(B7-1)单克隆抗体

产品号 #(选择产品)

产品号 #100-1599_C

小鼠抗人恒河猴CD80(B7-1)单克隆抗体

总览

该单克隆抗体(克隆号2D10.4)可特异性识别人源 CD80(也称为 B7-1),其为一种60 kDa的单链I型跨膜糖蛋白,属于免疫球蛋白超家族。CD80表达于已激活的B细胞、T细胞、巨噬细胞和树突状细胞表达。该重组单克隆抗体适用于检测 CD80 的相关应用,如流式细胞术(FC)。该抗体验证可用于标记在ImmunoCult™-SF 巨噬细胞培养基(目录号 #10961)中培养的 CD80⁺ 初代人源 M1 型巨噬细胞。细胞培养体系中含有人源重组M-CSF(产品号 #78057)、人源重组 IFN-γ(产品号 #78020)和来自大肠杆菌 O55:B5 的脂多糖(LPS,产品号 #100-1270)进行极化处理。
CD80具有与两种T细胞受体结合的高亲和力:CD28和CD152(也称为CTLA-4)。CD80与CD28的相互作用通过CD3复合物为T细胞激活提供了强有力的共刺激信号,而其与CD152的相互作用为T细胞激活提供了抑制信号。CD80与CD28的另一个配体CD86(也称为B7-2)一起在T细胞活化的调节中起主要作用。CD80功能障碍与胆囊鳞状细胞癌和心肌炎等疾病有关。该抗体也可用作评估经典激活的1型(M1)巨噬细胞的标记物。

亚型
一抗
 
靶抗原
CD80 (B7-1)
 
别名
B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7
 
活性物种
人,Rhesus
 
偶联
APC,PE
 
宿主物种
小鼠
 
细胞类型
B 细胞,树突状细胞(DCs),巨噬细胞,T 细胞
 
种属

 
应用
流式细胞术
 
研究领域
免疫
 
克隆
2D10.4
 
基因编号
941
 
同种型
IgG1,kappa
 

Data Figures

Flow Cytometry Data for Monocyte-Derived Macrophages Labeled with Anti-Human CD80 Antibody

Figure 1. Flow Cytometry Data for Monocyte-Derived Macrophages Labeled with Anti-Human CD80 Antibody

Flow cytometry analysis of primary human monocyte-derived macrophages polarized toward M1 (solid line histogram; purple) or M2a (solid line histogram; gold) subtypes cultured using ImmunoCult™-SF Macrophage Medium and labeled with Anti-Human CD80 Antibody, Clone 2D10.4, PE. Labeling of human monocyte-derived M1 macrophages with a mouse IgG1, kappa, PE isotype control antibody (Catalog #60070PE) is shown (filled histogram; grey).

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-1600
Lot #
All
Language
English
Catalog #
100-1599
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1600
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1599
Lot #
All
Language
English

Resources and Publications

Educational Materials (2)

更多信息

更多信息
Species Human
Clone 2D10.4
Gene Id 941
Alternative Names B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Isotype IgG1, kappa
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