产品号 #100-1347_C
Mouse monoclonal antibody against human CD69
概述
The monoclonal mouse CD69 antibody reacts with CD69, a gp28/34 disulfide bonded homodimer with a molecular weight of 60 kDa under non-reducing conditions. CD69, also known as the Very Early Activation Antigen, EA-1, Leu23, Activation Inducer Molecule (AIM) and CLEC2C, is a type II transmembrane protein that is constitutively expressed by activated platelets. Use this monoclonal antibody in applications requiring detection of CD69 such as flow cytometry (FC).
Studies show that CD69 crosslinking activates various events that lead to platelet activation and aggregation, such as calcium influx, degranulation, and arachidonate metabolism by cyclooxygenase. Upon activation of various lymphocytes, CD69 expression is induced in T cells, thymocytes, B cells, NK cells, neutrophils, and eosinophils, highlighting its role in lymphocyte signal transduction and activation. The protein also plays a role in signal transduction of natural killer cells and platelets. Diseases associated with CD69 dysfunction include coccidiodomycosis and asthma.
Subtype
Primary Antibodies
Target Antigen
CD69
Alternative Names
AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3
Reactive Species
Human
Conjugation
APC-Cyanine7, PE-Cyanine7, PerCP-Cyanine5.5
Host Species
Mouse
Cell Type
B Cells, Granulocytes and Subsets, NK Cells, T Cells
Species
Human
Application
Flow Cytometry
Area of Interest
Immunology, Stem Cell Biology
Clone
FN50
Gene ID
969
Isotype
IgG1, kappa
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet Product Name
Anti-Human CD69 (AIM) Antibody, Clone FN50, APC Catalog #
100-1349 Lot #
All Language
English Document Type
Product Information Sheet Product Name
Anti-Human CD69 (AIM) Antibody, Clone FN50, PE-Cy7 Catalog #
100-1347 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD69 (AIM) Antibody, Clone FN50, APC Catalog #
100-1349 Lot #
All Language
English Document Type
Safety Data Sheet Product Name
Anti-Human CD69 (AIM) Antibody, Clone FN50, PE-Cy7 Catalog #
100-1347 Lot #
All Language
English Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Resources and Publications
Educational Materials (2)
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